Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0447 Transporter Info
Gene Name	SLC6A15
Transporter Name	Sodium-dependent neutral amino acid transporter B(0)AT2
Gene ID	55117
UniProt ID	Q9H2J7

Post-Translational Modification of This DT
Overview ofSLC6A15 Modification Sites with Functional and Structural Information
Sequence	M P K N S K V V K R E L D D D V T E S V K D L L S N E D A A D D A F K T S E L I V D G Q E E K D T D V E E G S E V E D E R P A W N S K L Q Y I L A Q V G F S V G L G N V W R F P Y L C Q K N G G G A Y L L P Y L I L L M V I G I P L F F L E L S V G Q R I R R G S I G V W N Y I S P K L G G I G F A S C V V C Y F V A L Y Y N V I I G W S L F Y F S Q S F Q Q P L P W D Q C P L V K N A S H T F V E P E C E Q S S A T T Y Y W Y R E A L N I S S S I S E S G G L N W K M T I C L L A A W V M V C L A M I K G I Q S S G K I I Y F S S L F P Y V V L I C F L I R A F L L N G S I D G I R H M F T P K L E I M L E P K V W R E A A T Q V F F A L G L G F G G V I A F S S Y N K R D N N C H F D A V L V S F I N F F T S V L A T L V V F A V L G F K A N V I N E K C I T Q N S E T I M K F L K M G N I S Q D I I P H H I N L S T V T A E D Y H L V Y D I I Q K V K E E E F P A L H L N S C K I E E E L N K A V Q G T G L A F I A F T E A M T H F P A S P F W S V M F F L M L V N L G L G S M F G T I E G I V T P I V D T F K V R K E I L T V I C C L L A F C I G L I F V Q R S G N Y F V T M F D D Y S A T L P L L I V V I L E N I A V C F V Y G I D K F M E D L K D M L G F A P S R Y Y Y Y M W K Y I S P L M L L S L L I A S V V N M G L S P P G Y N A W I E D K A S E E F L S Y P T W G L V V C V S L V V F A I L P V P V V F I V R R F N L I D D S S G N L A S V T Y K R G R V L K E P V N L E G D D T S L I H G K I P S E M P S P N F G K N I Y R K Q S G S P T L D T A P N G R Y G I G Y L M A D I M P D M P E S D L
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	187
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A15 Asparagine 187 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A15			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	213
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A15 Asparagine 213 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A15			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	383
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A15 Asparagine 383 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A15			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	394
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A15 Asparagine 394 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	91
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC6A15 Cystine 91 has the potential to affect its expression or activity.
Phosphorylation
Serine	15 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	19
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 19 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A15			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	25
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 25 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A15			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	37
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 37 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A15			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	55
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 55 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC6A15			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	66
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 66 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC6A15			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	129
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 129 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC6A15			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 137 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC6A15			[9], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	648
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 648 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC6A15			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	649
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 649 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC6A15			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	654
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 654 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC6A15			[3], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	675
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 675 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC6A15			[3], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	683
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 683 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC6A15			[3], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	687
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 687 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC6A15			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	699
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 699 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC6A15			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	701
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Serine 701 has the potential to affect its expression or activity.
Threonine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[9], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	17
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 17 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A15			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	36
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 36 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A15			[3], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	49
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 49 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A15			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	656
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 656 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC6A15			[3], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	674
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 674 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC6A15			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	703
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 703 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC6A15			[18], [19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	706
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Threonine 706 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[20]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	657
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A15 Tyrosine 657 has the potential to affect its expression or activity.
Ubiquitination
Asparticacid	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[21]
Role of PTM	Potential impacts
Modified Residue	Asparticacid	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Asparticacid 551 has the potential to affect its expression or activity.
Lysine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A15			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	21
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 21 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A15			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	35
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 35 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A15			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	658
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 658 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A15			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	664
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 664 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	692
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 692 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	692
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 692 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	692
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 692 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	697
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 697 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	697
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 697 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[23]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	697
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A15 Lysine 697 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S6A15_HUMAN)
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
4	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
5	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
6	Rapid combinatorial ERLIC-SCX solid-phase extraction for in-depth phosphoproteome analysis. J Proteome Res. 2013 Dec 6;12(12):5989-95.
7	Combination of multistep IMAC enrichment with high-pH reverse phase separation for in-depth phosphoproteomic profiling. J Proteome Res. 2013 Sep 6;12(9):4176-86.
8	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
9	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
10	Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence. Mol Cell Proteomics. 2014 Aug;13(8):2089-100.
11	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
12	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
13	Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun. 2019 Jan 10;10(1):104.
14	Modulation of Cl- signaling and ion transport by recruitment of kinases and phosphatases mediated by the regulatory protein IRBIT. Sci Signal. 2018 Oct 30;11(554):eaat5018.
15	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
16	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
17	An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 Sep;561(7722):253-257.
18	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
19	Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling. J Proteome Res. 2017 Mar 3;16(3):1121-1132.
20	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
21	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.
22	Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res. 2012 Feb 3;11(2):796-807.
23	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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