Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0443 Transporter Info
Gene Name	SLC6A11
Transporter Name	Sodium- and chloride-dependent GABA transporter 3
Gene ID	6538
UniProt ID	P48066

Post-Translational Modification of This DT
Overview ofSLC6A11 Modification Sites with Functional and Structural Information
Sequence	M T A E K A L P L G N G K A A E E A R E S E A P G G G C S S G G A A P A R H P R V K R D K A V H E R G H W N N K V E F V L S V A G E I I G L G N V W R F P Y L C Y K N G G G A F L I P Y V V F F I C C G I P V F F L E T A L G Q F T S E G G I T C W R K V C P L F E G I G Y A T Q V I E A H L N V Y Y I I I L A W A I F Y L S N C F T T E L P W A T C G H E W N T E N C V E F Q K L N V S N Y S H V S L Q N A T S P V M E F W E H R V L A I S D G I E H I G N L R W E L A L C L L A A W T I C Y F C I W K G T K S T G K V V Y V T A T F P Y I M L L I L L I R G V T L P G A S E G I K F Y L Y P D L S R L S D P Q V W V D A G T Q I F F S Y A I C L G C L T A L G S Y N N Y N N N C Y R D C I M L C C L N S G T S F V A G F A I F S V L G F M A Y E Q G V P I A E V A E S G P G L A F I A Y P K A V T M M P L S P L W A T L F F M M L I F L G L D S Q F V C V E S L V T A V V D M Y P K V F R R G Y R R E L L I L A L S V I S Y F L G L V M L T E G G M Y I F Q L F D S Y A A S G M C L L F V A I F E C I C I G W V Y G S N R F Y D N I E D M I G Y R P P S L I K W C W M I M T P G I C A G I F I F F L I K Y K P L K Y N N I Y T Y P A W G Y G I G W L M A L S S M L C I P L W I C I T V W K T E G T L P E K L Q K L T T P S T D L K M R G K L G V S P R M V T V N D C D A K L K S D G T I A A I T E K E T H F
PTM type	X-Acetylation X-N-glycosylation X-Oxidation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A11			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	583
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC6A11 Lysine 583 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A11			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	187
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A11 Asparagine 187 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A11			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	190
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A11 Asparagine 190 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A11			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	198
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC6A11 Asparagine 198 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A11			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	80
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC6A11 Cystine 80 has the potential to affect its expression or activity.
Phosphorylation
Serine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A11			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	21
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Serine 21 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A11			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	29
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Serine 29 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC6A11			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	30
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Serine 30 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC6A11			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	510
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Serine 510 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC6A11			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	591
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Serine 591 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC6A11			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	603
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Serine 603 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A11			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	274
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Threonine 274 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A11			[6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	592
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC6A11 Threonine 592 has the potential to affect its expression or activity.
Ubiquitination
Lysine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC6A11			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	13
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A11 Lysine 13 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC6A11			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	617
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A11 Lysine 617 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	628
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A11 Lysine 628 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[9]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	628
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC6A11 Lysine 628 has the potential to affect its expression or activity.

References
1	The Ukrainian language in the medical environment. Its current status and the outlook. Lik Sprava. 1994 Mar-Apr;(3-4):133-7.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: S6A11_HUMAN)
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27.
5	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
6	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
7	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
8	Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease. Proteomics. 2018 Oct;18(20):e1800108.
9	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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