Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0371 Transporter Info
Gene Name	SLC45A4
Transporter Name	Solute carrier family 45 member 4
Gene ID	57210
UniProt ID	Q5BKX6

Post-Translational Modification of This DT
Overview ofSLC45A4 Modification Sites with Functional and Structural Information
Sequence	M K M A P Q N A D P E S M Q V Q E L S V P L P D P Q K A G G A E A E N C E T I S E G S I D R I P M R L W V M H G A V M F G R E F C Y A M E T A L V T P I L L Q I G L P E Q Y Y S L T W F L S P I L G L I F T P L I G S A S D R C T L S W G R R R P F I L A L C V G V L F G V A L F L N G S A I G L A L G D V P N R Q P I G I V L T V L G V V V L D F S A D A T E G P I R A Y L L D V V D S E E Q D M A L N I H A F S A G L G G A I G Y V L G G L D W T Q T F L G S W F R T Q N Q V L F F F A A I I F T V S V A L H L F S I D E E Q Y S P Q Q E R S A E E P G A L D G G E P H G V P A F P D E V Q S E H E L A L D Y P D V D I M R S K S D S A L H V P D T A L D L E P E L L F L H D I E P S I F H D A S Y P A T P R S T S Q E L A K T K L P R L A T F L K E A A K E D E T L L D N H L N E A K V P N G S G S P T K D A L G G Y T R V D T K P S A T S S S M R R R R H A F R R Q A S S T F S Y Y G K L G S H C Y R Y R R A N A V V L I K P S R S M S D L Y D M Q K R Q R Q H R H R N Q S G A T T S S G D T E S E E G E G E T T V R L L W L S M L K M P R E L M R L C L C H L L T W F S V I A E A V F Y T D F M G Q V I F E G D P K A P S N S T A W Q A Y N A G V K M G C W G L V I Y A A T G A I C S A L L Q K Y L D N Y D L S V R V I Y V L G T L G F S V G T A V M A M F P N V Y V A M V T I S T M G I V S M S I S Y C P Y A L L G Q Y H D I K Q Y I H H S P G N S K R G F G I D C A I L S C Q V Y I S Q I L V A S A L G G V V D A V G T V R V I P M V A S V G S F L G F L T A T F L V I Y P N V S E E A K E E Q K G L S S P L A G E G R A G G N S E K P T V L K L T R K E G L Q G P V E T E S V V
PTM type	X-Phosphorylation X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	33 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A4			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	40
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 40 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A4			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	43
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 43 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC45A4			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 265 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC45A4			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	289
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 289 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC45A4			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	305
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 305 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC45A4			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	307
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 307 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC45A4			[6], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	309
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 309 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC45A4			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	333
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 333 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC45A4			[6], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	339
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 339 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC45A4			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	346
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 346 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC45A4			[1], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	348
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 348 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC45A4			[4], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	387
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 387 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC45A4			[4], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 389 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC45A4			[1], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	406
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 406 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC45A4			[1], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	409
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 409 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC45A4			[1], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	410
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 410 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC45A4			[1], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	411
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 411 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SLC45A4			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	424
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 424 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence SLC45A4			[1], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	425
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 425 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence SLC45A4			[14], [15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	428
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 428 has the potential to affect its expression or activity.
PTM Phenomenon21	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon22	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon23	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon24	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon25	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon26	.			[16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	435
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 435 has the potential to affect its expression or activity.
PTM Phenomenon27	Have the potential to influence SLC45A4			[17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	452
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 452 has the potential to affect its expression or activity.
PTM Phenomenon28	Have the potential to influence SLC45A4			[13], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	454
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 454 has the potential to affect its expression or activity.
PTM Phenomenon29	Have the potential to influence SLC45A4			[12], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	456
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 456 has the potential to affect its expression or activity.
PTM Phenomenon30	Have the potential to influence SLC45A4			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	485
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 485 has the potential to affect its expression or activity.
PTM Phenomenon31	Have the potential to influence SLC45A4			[1], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	731
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 731 has the potential to affect its expression or activity.
PTM Phenomenon32	Have the potential to influence SLC45A4			[3], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	732
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 732 has the potential to affect its expression or activity.
PTM Phenomenon33	Have the potential to influence SLC45A4			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	766
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Serine 766 has the potential to affect its expression or activity.
Threonine	12 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A4			[1], [2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	38
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 38 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A4			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	316
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 316 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC45A4			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	343
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 343 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC45A4			[4], [9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	347
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 347 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC45A4			[19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	361
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 361 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC45A4			[21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 372 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC45A4			[11], [19]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	391
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 391 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC45A4			[22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	403
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 403 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC45A4			[1], [22]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	408
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 408 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC45A4			[1], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	426
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 426 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC45A4			[2], [23]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	483
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 483 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC45A4			[19], [20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	764
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Threonine 764 has the potential to affect its expression or activity.
Tyrosine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC45A4			[2], [24]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	297
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Tyrosine 297 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC45A4			[25]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	429
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Tyrosine 429 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC45A4			[25]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	430
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Tyrosine 430 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC45A4			[26], [27]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	459
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC45A4 Tyrosine 459 has the potential to affect its expression or activity.
Ubiquitination
Lysine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	382
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 382 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	404
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 404 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 463 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 463 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 463 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	728
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 728 has the potential to affect its expression or activity.
PTM Phenomenon7	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	746
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 746 has the potential to affect its expression or activity.
PTM Phenomenon8	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	746
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 746 has the potential to affect its expression or activity.
PTM Phenomenon9	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	746
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 746 has the potential to affect its expression or activity.
PTM Phenomenon10	.			[16]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	751
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 751 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC45A4			[28]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	755
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC45A4 Lysine 755 has the potential to affect its expression or activity.

References
1	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
2	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
3	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
4	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
5	Comparison of SILAC and mTRAQ quantification for phosphoproteomics on a quadrupole orbitrap mass spectrometer. J Proteome Res. 2013 Sep 6;12(9):4089-100.
6	Protein kinase C-alpha interaction with F0F1-ATPase promotes F0F1-ATPase activity and reduces energy deficits in injured renal cells. J Biol Chem. 2015 Mar 13;290(11):7054-66.
7	Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep. 2014 Sep 11;8(5):1583-94.
8	Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer. Mol Cancer Res. 2016 Oct;14(10):1019-1029.
9	Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood. 2017 Jan 12;129(2):e1-e12.
10	Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells. J Proteome Res. 2016 Dec 2;15(12):4490-4504.
11	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
12	Tip-Based Fractionation of Batch-Enriched Phosphopeptides Facilitates Easy and Robust Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):46-54.
13	UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515.
14	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
15	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
16	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
17	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
18	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
19	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
20	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
21	Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jan 1;879(1):25-34.
22	Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27.
23	Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome. Proteomics. 2015 Jan;15(2-3):500-7.
24	HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread. Cell Rep. 2017 Jan 24;18(4):1062-1074.
25	Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.
26	Improved Method for Determining Absolute Phosphorylation Stoichiometry Using Bayesian Statistics and Isobaric Labeling. J Proteome Res. 2017 Nov 3;16(11):4217-4226.
27	Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS. Elife. 2017 Oct 20;6:e27574.
28	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.

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Detail Information of Post-Translational Modifications

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