Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0351 Transporter Info
Gene Name	SLC3A1
Transporter Name	Neutral and basic amino acid transport protein rBAT
Gene ID	6519
UniProt ID	Q07837

Post-Translational Modification of This DT
Overview ofSLC3A1 Modification Sites with Functional and Structural Information
Sequence	M A E D K S K R D S I E M S M K G C Q T N N G F V H N E D I L E Q T P D P G S S T D N L K H S T R G I L G S Q E P D F K G V Q P Y A G M P K E V L F Q F S G Q A R Y R I P R E I L F W L T V A S V L V L I A A T I A I I A L S P K C L D W W Q E G P M Y Q I Y P R S F K D S N K D G N G D L K G I Q D K L D Y I T A L N I K T V W I T S F Y K S S L K D F R Y G V E D F R E V D P I F G T M E D F E N L V A A I H D K G L K L I I D F I P N H T S D K H I W F Q L S R T R T G K Y T D Y Y I W H D C T H E N G K T I P P N N W L S V Y G N S S W H F D E V R N Q C Y F H Q F M K E Q P D L N F R N P D V Q E E I K E I L R F W L T K G V D G F S L D A V K F L L E A K H L R D E I Q V N K T Q I P D T V T Q Y S E L Y H D F T T T Q V G M H D I V R S F R Q T M D Q Y S T E P G R Y R F M G T E A Y A E S I D R T V M Y Y G L P F I Q E A D F P F N N Y L S M L D T V S G N S V Y E V I T S W M E N M P E G K W P N W M I G G P D S S R L T S R L G N Q Y V N V M N M L L F T L P G T P I T Y Y G E E I G M G N I V A A N L N E S Y D I N T L R S K S P M Q W D N S S N A G F S E A S N T W L P T N S D Y H T V N V D V Q K T Q P R S A L K L Y Q D L S L L H A N E L L L N R G W F C H L R N D S H Y V V Y T R E L D G I D R I F I V V L N F G E S T L L N L H N M I S G L P A K M R I R L S T N S A D K G S K V D T S G I F L D K G E G L I F E H N T K N L L H R Q T A F R D R C F V S N R A C Y S S V L N I L Y T S C
PTM type	X-Acetylation X-N-glycosylation X-Phosphorylation X-Phosphorylation X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	219
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC3A1 Lysine 219 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC3A1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	214
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC3A1 Asparagine 214 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC3A1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	261
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC3A1 Asparagine 261 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC3A1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	332
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC3A1 Asparagine 332 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC3A1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	495
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC3A1 Asparagine 495 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC3A1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	513
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC3A1 Asparagine 513 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC3A1			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	575
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC3A1 Asparagine 575 has the potential to affect its expression or activity.
Phosphorylation
Serine	10 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 6 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC3A1			[3], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 10 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC3A1			[3], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	14
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 14 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	39
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 39 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	40
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 40 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	47
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 47 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	54
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 54 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC3A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	111
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 111 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC3A1			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	134
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 134 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC3A1			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	372
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Serine 372 has the potential to affect its expression or activity.
Threonine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	41
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Threonine 41 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC3A1			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	48
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Threonine 48 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC3A1			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	243
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Threonine 243 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC3A1			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	367
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Threonine 367 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC3A1			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	373
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Threonine 373 has the potential to affect its expression or activity.
PTM Phenomenon6	.			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	471
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Threonine 471 has the potential to affect its expression or activity.
Tyrosine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC3A1			[8], [9]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	236
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Tyrosine 236 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC3A1			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	371
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Tyrosine 371 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC3A1			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Tyrosine 378 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[1]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	461
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC3A1 Tyrosine 461 has the potential to affect its expression or activity.

References
1	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SLC31_HUMAN)
3	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
4	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
5	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
6	Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis. J Proteome Res. 2015 Sep 4;14(9):4087-98.
7	Characterization of native protein complexes and protein isoform variation using size-fractionation-based quantitative proteomics. Mol Cell Proteomics. 2013 Dec;12(12):3851-73.
8	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
9	Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14112-7.

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Detail Information of Post-Translational Modifications

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