Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0165 Transporter Info
Gene Name	SLC24A4
Transporter Name	Sodium/potassium/calcium exchanger 4
Gene ID	123041
UniProt ID	Q8NFF2

Post-Translational Modification of This DT
Overview ofSLC24A4 Modification Sites with Functional and Structural Information
Sequence	M A L R G T L R P L K V R R R R E M L P Q Q V G F V C A V L A L V C C A S G L F G S L G H K T A S A S K R V L P D T W R N R K L M A P V N G T Q T A K N C T D P A I H E F P T D L F S N K E R Q H G A V L L H I L G A L Y M F Y A L A I V C D D F F V P S L E K I C E R L H L S E D V A G A T F M A A G S S T P E L F A S V I G V F I T H G D V G V G T I V G S A V F N I L C I I G V C G L F A G Q V V R L T W W A V C R D S V Y Y T I S V I V L I V F I Y D E Q I V W W E G L V L I I L Y V F Y I L I M K Y N V K M Q A F F T V K Q K S I A N G N P V N S E L E A G N D F Y D G S Y D D P S V P L L G Q V K E K P Q Y G K N P V V M V D E I M S S S P P K F T F P E A G L R I M I T N K F G P R T R L R M A S R I I I N E R Q R L I N S A N G V S S K P L Q N G R H E N I E N G N V P V E N P E D P Q Q N Q E Q Q P P P Q P P P P E P E P V E A D F L S P F S V P E A R G D K V K W V F T W P L I F L L C V T I P N C S K P R W E K F F M V T F I T A T L W I A V F S Y I M V W L V T I I G Y T L G I P D V I M G I T F L A A G T S V P D C M A S L I V A R Q G L G D M A V S N T I G S N V F D I L V G L G V P W G L Q T M V V N Y G S T V K I N S R G L V Y S V V L L L G S V A L T V L G I H L N K W R L D R K L G V Y V L V L Y A I F L C F S I M I E F N V F T F V N L P M C R E D D
PTM type	X-N-glycosylation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A4			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	69
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC24A4 Asparagine 69 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A4			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	76
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC24A4 Asparagine 76 has the potential to affect its expression or activity.
Phosphorylation
Serine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A4			[2]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	362
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A4 Serine 362 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC24A4			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	363
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A4 Serine 363 has the potential to affect its expression or activity.
Threonine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC24A4			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A4 Threonine 6 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	143
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC24A4 Threonine 143 has the potential to affect its expression or activity.
Ubiquitination
Lysine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	75
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC24A4 Lysine 75 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[6]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	75
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC24A4 Lysine 75 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: NCKX4_HUMAN)
2	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
5	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
6	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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