Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0136 Transporter Info
Gene Name	SLC20A1
Transporter Name	Sodium-dependent phosphate transporter 1
Gene ID	6574
UniProt ID	Q8WUM9

Post-Translational Modification of This DT
Overview ofSLC20A1 Modification Sites with Functional and Structural Information
Sequence	M A T L I T S T T A A T A A S G P L V D Y L W M L I L G F I I A F V L A F S V G A N D V A N S F G T A V G S G V V T L K Q A C I L A S I F E T V G S V L L G A K V S E T I R K G L I D V E M Y N S T Q G L L M A G S V S A M F G S A V W Q L V A S F L K L P I S G T H C I V G A T I G F S L V A K G Q E G V K W S E L I K I V M S W F V S P L L S G I M S G I L F F L V R A F I L H K A D P V P N G L R A L P V F Y A C T V G I N L F S I M Y T G A P L L G F D K L P L W G T I L I S V G C A V F C A L I V W F F V C P R M K R K I E R E I K C S P S E S P L M E K K N S L K E D H E E T K L S V G D I E N K H P V S E V G P A T V P L Q A V V E E R T V S F K L G D L E E A P E R E R L P S V D L K E E T S I D S T V N G A V Q L P N G N L V Q F S Q A V S N Q I N S S G H Y Q Y H T V H K D S G L Y K E L L H K L H L A K V G D C M G D S G D K P L R R N N S Y T S Y T M A I C G M P L D S F R A K E G E Q K G E E M E K L T W P N A D S K K R I R M D S Y T S Y C N A V S D L H S A S E I D M S V K A E M G L G D R K G S N G S L E E W Y D Q D K P E V S L L F Q F L Q I L T A C F G S F A H G G N D V S N A I G P L V A L Y L V Y D T G D V S S K V A T P I W L L L Y G G V G I C V G L W V W G R R V I Q T M G K D L T P I T P S S G F S I E L A S A L T V V I A S N I G L P I S T T H C K V G S V V S V G W L R S K K A V D W R L F R N I F M A W F V T V P I S G V I S A A I M A I F R Y V I L R M
PTM type	X-Phosphorylation X-Ubiquitination X-Ubiquitination X: Amino Acid

Phosphorylation
Serine	20 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC20A1			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	121
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 121 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC20A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	265
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 265 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC20A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	267
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 267 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC20A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	269
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 269 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC20A1			[4], [5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	277
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 277 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC20A1			[4], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	288
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 288 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC20A1			[5], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	299
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 299 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC20A1			[5], [8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	318
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 318 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC20A1			[4], [9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	335
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 335 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC20A1			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	385
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 385 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC20A1			[4], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	417
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 417 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC20A1			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	420
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 420 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC20A1			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	432
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 432 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC20A1			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	455
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 455 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC20A1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	463
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 463 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC20A1			[16], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	466
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 466 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC20A1			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	472
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 472 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SLC20A1			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	476
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 476 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence SLC20A1			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	478
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 478 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence SLC20A1			[16], [19]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	483
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Serine 483 has the potential to affect its expression or activity.
Threonine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC20A1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	285
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Threonine 285 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC20A1			[20]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	305
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Threonine 305 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC20A1			[5], [21]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	316
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Threonine 316 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC20A1			[12], [15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	419
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Threonine 419 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC20A1			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	422
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Threonine 422 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC20A1			[16], [17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	465
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Threonine 465 has the potential to affect its expression or activity.
Tyrosine	7 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC20A1			[22]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	376
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 376 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC20A1			[22]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	378
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 378 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC20A1			[10], [11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	388
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 388 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC20A1			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	418
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 418 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC20A1			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	421
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 421 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC20A1			[19], [23]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	464
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 464 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC20A1			[19], [23]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	467
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC20A1 Tyrosine 467 has the potential to affect its expression or activity.
Ubiquitination
Lysine	13 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	263
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 263 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	275
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 275 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	279
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 279 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	286
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 286 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	295
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 295 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	320
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 320 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	389
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 389 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	394
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 394 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	436
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 436 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	441
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 441 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	447
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 447 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC20A1			[25], [26]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	456
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 456 has the potential to affect its expression or activity.
PTM Phenomenon13	.			[24]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	485
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC20A1 Lysine 485 has the potential to affect its expression or activity.

References
1	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
2	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
3	Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun. 2019 Jan 10;10(1):104.
4	Robust, Reproducible, and Economical Phosphopeptide Enrichment Using Calcium Titanate. J Proteome Res. 2019 Mar 1;18(3):1411-1417.
5	CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-beta/BMP Signaling at the Primary Cilium. Cell Rep. 2018 Mar 6;22(10):2584-2592.
6	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun. 2018 Mar 9;9(1):1017.
7	Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Rep. 2016 Apr 12;15(2):436-50.
8	Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics. Front Cell Dev Biol. 2017 Nov 22;5:97.
9	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
10	Deep Phosphotyrosine Proteomics by Optimization of Phosphotyrosine Enrichment and MS/MS Parameters. J Proteome Res. 2017 Feb 3;16(2):1077-1086.
11	Sensitive, Robust, and Cost-Effective Approach for Tyrosine Phosphoproteome Analysis. Anal Chem. 2017 Sep 5;89(17):9307-9314.
12	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
13	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
14	HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread. Cell Rep. 2017 Jan 24;18(4):1062-1074.
15	Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. Mol Syst Biol. 2018 Mar 5;14(3):e7858.
16	Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment. Mol Cell Proteomics. 2018 May;17(5):1028-1034.
17	Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry. J Proteome Res. 2018 Apr 6;17(4):1654-1663.
18	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle. J Biol Chem. 2017 Sep 1;292(35):14311-14324.
19	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
20	A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2015 Jun;14(6):1599-615.
21	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
22	Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. PLoS Comput Biol. 2015 Apr 17;11(4):e1004130.
23	Phosphoproteomics reveals ALK promote cell progress via RAS/ JNK pathway in neuroblastoma. Oncotarget. 2016 Nov 15;7(46):75968-75980.
24	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.
25	Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 2011 Oct 21;44(2):325-40.
26	Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J Proteome Res. 2012 Feb 3;11(2):796-807.

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Detail Information of Post-Translational Modifications

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