Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0096 Transporter Info
Gene Name	SLC14A1
Transporter Name	Urea transporter 1
Gene ID	6563
UniProt ID	Q13336

Post-Translational Modification of This DT
Overview ofSLC14A1 Modification Sites with Functional and Structural Information
Sequence	M E D S P T M V R V D S P T M V R G E N Q V S P C Q G R R C F P K A L G Y V T G D M K E L A N Q L K D K P V V L Q F I D W I L R G I S Q V V F V N N P V S G I L I L V G L L V Q N P W W A L T G W L G T V V S T L M A L L L S Q D R S L I A S G L Y G Y N A T L V G V L M A V F S D K G D Y F W W L L L P V C A M S M T C P I F S S A L N S M L S K W D L P V F T L P F N M A L S M Y L S A T G H Y N P F F P A K L V I P I T T A P N I S W S D L S A L E L L K S I P V G V G Q I Y G C D N P W T G G I F L G A I L L S S P L M C L H A A I G S L L G I A A G L S L S A P F E D I Y F G L W G F N S S L A C I A M G G M F M A L T W Q T H L L A L G C A L F T A Y L G V G M A N F M A E V G L P A C T W P F C L A T L L F L I M T T K N S N I Y K M P L S K V T Y P E E N R I F Y L Q A K K R M V E S P L
PTM type	X-N-glycosylation X-Phosphorylation X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC14A1			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	211
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC14A1 Asparagine 211 has the potential to affect its expression or activity.
Phosphorylation
Serine	8 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC14A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	4
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 4 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC14A1			[2], [4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	12
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 12 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	137
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 137 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	154
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 154 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	161
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 161 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	162
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 162 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	166
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 166 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC14A1			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	169
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Serine 169 has the potential to affect its expression or activity.
Threonine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC14A1			[2], [3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	6
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Threonine 6 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC14A1			[4], [7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	14
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Threonine 14 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	156
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Threonine 156 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC14A1			[5]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	142
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC14A1 Tyrosine 142 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: UT1_HUMAN)
2	Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors. Mol Syst Biol. 2018 Mar 5;14(3):e7858.
3	Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer. J Proteome Res. 2017 Dec 1;16(12):4364-4373.
4	Phosphoproteome profiling revealed abnormally phosphorylated AMPK and ATF2 involved in glucose metabolism and tumorigenesis of GH-PAs. J Endocrinol Invest. 2019 Feb;42(2):137-148.
5	Rapid combinatorial ERLIC-SCX solid-phase extraction for in-depth phosphoproteome analysis. J Proteome Res. 2013 Dec 6;12(12):5989-95.
6	Comparative N-glycoproteomic and phosphoproteomic profiling of human placental plasma membrane between normal and preeclampsia pregnancies with high-resolution mass spectrometry. PLoS One. 2013 Nov 15;8(11):e80480.
7	Phosphoproteins in extracellular vesicles as candidate markers for breast cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3175-3180.

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Detail Information of Post-Translational Modifications

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