Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0061 Transporter Info
Gene Name	ABCC8
Transporter Name	Sulfonylurea receptor 1
Gene ID	6833
UniProt ID	Q09428

Post-Translational Modification of This DT
Overview ofABCC8 Modification Sites with Functional and Structural Information
Sequence	M P L A F C G S E N H S A A Y R V D Q G V L N N G C F V D A L N V V P H V F L L F I T F P I L F I G W G S Q S S K V H I H H S T W L H F P G H N L R W I L T F M L L F V L V C E I A E G I L S D G V T E S H H L H L Y M P A G M A F M A A V T S V V Y Y H N I E T S N F P K L L I A L L V Y W T L A F I T K T I K F V K F L D H A I G F S Q L R F C L T G L L V I L Y G M L L L V E V N V I R V R R Y I F F K T P R E V K P P E D L Q D L G V R F L Q P F V N L L S K G T Y W W M N A F I K T A H K K P I D L R A I G K L P I A M R A L T N Y Q R L C E A F D A Q V R K D I Q G T Q G A R A I W Q A L S H A F G R R L V L S S T F R I L A D L L G F A G P L C I F G I V D H L G K E N D V F Q P K T Q F L G V Y F V S S Q E F L A N A Y V L A V L L F L A L L L Q R T F L Q A S Y Y V A I E T G I N L R G A I Q T K I Y N K I M H L S T S N L S M G E M T A G Q I C N L V A I D T N Q L M W F F F L C P N L W A M P V Q I I V G V I L L Y Y I L G V S A L I G A A V I I L L A P V Q Y F V A T K L S Q A Q R S T L E Y S N E R L K Q T N E M L R G I K L L K L Y A W E N I F R T R V E T T R R K E M T S L R A F A I Y T S I S I F M N T A I P I A A V L I T F V G H V S F F K E A D F S P S V A F A S L S L F H I L V T P L F L L S S V V R S T V K A L V S V Q K L S E F L S S A E I R E E Q C A P H E P T P Q G P A S K Y Q A V P L R V V N R K R P A R E D C R G L T G P L Q S L V P S A D G D A D N C C V Q I M G G Y F T W T P D G I P T L S N I T I R I P R G Q L T M I V G Q V G C G K S S L L L A A L G E M Q K V S G A V F W S S L P D S E I G E D P S P E R E T A T D L D I R K R G P V A Y A S Q K P W L L N A T V E E N I I F E S P F N K Q R Y K M V I E A C S L Q P D I D I L P H G D Q T Q I G E R G I N L S G G Q R Q R I S V A R A L Y Q H A N V V F L D D P F S A L D I H L S D H L M Q A G I L E L L R D D K R T V V L V T H K L Q Y L P H A D W I I A M K D G T I Q R E G T L K D F Q R S E C Q L F E H W K T L M N R Q D Q E L E K E T V T E R K A T E P P Q G L S R A M S S R D G L L Q D E E E E E E E A A E S E E D D N L S S M L H Q R A E I P W R A C A K Y L S S A G I L L L S L L V F S Q L L K H M V L V A I D Y W L A K W T D S A L T L T P A A R N C S L S Q E C T L D Q T V Y A M V F T V L C S L G I V L C L V T S V T V E W T G L K V A K R L H R S L L N R I I L A P M R F F E T T P L G S I L N R F S S D C N T I D Q H I P S T L E C L S R S T L L C V S A L A V I S Y V T P V F L V A L L P L A I V C Y F I Q K Y F R V A S R D L Q Q L D D T T Q L P L L S H F A E T V E G L T T I R A F R Y E A R F Q Q K L L E Y T D S N N I A S L F L T A A N R W L E V R M E Y I G A C V V L I A A V T S I S N S L H R E L S A G L V G L G L T Y A L M V S N Y L N W M V R N L A D M E L Q L G A V K R I H G L L K T E A E S Y E G L L A P S L I P K N W P D Q G K I Q I Q N L S V R Y D S S L K P V L K H V N A L I A P G Q K I G I C G R T G S G K S S F S L A F F R M V D T F E G H I I I D G I D I A K L P L H T L R S R L S I I L Q D P V L F S G T I R F N L D P E R K C S D S T L W E A L E I A Q L K L V V K A L P G G L D A I I T E G G E N F S Q G Q R Q L F C L A R A F V R K T S I F I M D E A T A S I D M A T E N I L Q K V V M T A F A D R T V V T I A H R V H T I L S A D L V I V L K R G A I L E F D K P E K L L S R K D S V F A S F V R A D K
PTM type	X-N-glycosylation X-Oxidation X-Phosphorylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	10
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC8 Asparagine 10 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	1049
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCC8 Asparagine 1049 has the potential to affect its expression or activity.
Oxidation
Cystine	2 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC8			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	717
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC8 Cystine 717 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC8			[2]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	921
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at ABCC8 Cystine 921 has the potential to affect its expression or activity.
Phosphorylation
Serine	13 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC8			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	165
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 165 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC8			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	302
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 302 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC8			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	611
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 611 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	720
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 720 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCC8			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	979
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 979 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCC8			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	986
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 986 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCC8			[6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	987
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 987 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCC8			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1324
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 1324 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1355
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 1355 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1356
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 1356 has the potential to affect its expression or activity.
PTM Phenomenon11	.			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1446
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 1446 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCC8			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1500
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 1500 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCC8			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1510
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Serine 1510 has the potential to affect its expression or activity.
Threonine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC8			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	912
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Threonine 912 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	949
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Threonine 949 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC8			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1320
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Threonine 1320 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCC8			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1499
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Threonine 1499 has the potential to affect its expression or activity.
Tyrosine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCC8			[11]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	798
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Tyrosine 798 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCC8			[7]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1325
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Tyrosine 1325 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCC8			[1]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1353
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCC8 Tyrosine 1353 has the potential to affect its expression or activity.
Ubiquitination
Lysine	5 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	205
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC8 Lysine 205 has the potential to affect its expression or activity.
PTM Phenomenon2	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	528
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC8 Lysine 528 has the potential to affect its expression or activity.
PTM Phenomenon3	.			[12]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	528
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC8 Lysine 528 has the potential to affect its expression or activity.
PTM Phenomenon4	.			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	889
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC8 Lysine 889 has the potential to affect its expression or activity.
PTM Phenomenon5	.			[8]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	1358
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCC8 Lysine 1358 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: ABCC8_HUMAN)
2	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence. Mol Cell Proteomics. 2014 Aug;13(8):2089-100.
5	Comparison of SILAC and mTRAQ quantification for phosphoproteomics on a quadrupole orbitrap mass spectrometer. J Proteome Res. 2013 Sep 6;12(9):4089-100.
6	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J. 2015 Nov 12;34(22):2840-61.
7	Phosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 Acute Myeloid Leukemia (AML) Cells. Mol Cell Proteomics. 2017 Jul;16(7):1365-1376.
8	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
9	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
10	Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS/MS proteomics and phosphoproteomics. Anal Bioanal Chem. 2017 Jul;409(19):4615-4625.
11	A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. Curr Med Res Opin. 1977;5(1):64-73.
12	ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins. Nucleic Acids Res. 2018;46(D1):D901-D910.

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Detail Information of Post-Translational Modifications

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