Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0045 Transporter Info
Gene Name	ABCA7
Transporter Name	ATP-binding cassette sub-family A member 7
Gene ID	10347
UniProt ID	Q8IZY2

Post-Translational Modification of This DT
Overview ofABCA7 Modification Sites with Functional and Structural Information
Sequence	M A F W T Q L M L L L W K N F M Y R R R Q P V Q L L V E L L W P L F L F F I L V A V R H S H P P L E H H E C H F P N K P L P S A G T V P W L Q G L I C N V N N T C F P Q L T P G E E P G R L S N F N D S L V S R L L A D A R T V L G G A S A H R T L A G L G K L I A T L R A A R S T A Q P Q P T K Q S P L E P P M L D V A E L L T S L L R T E S L G L A L G Q A Q E P L H S L L E A A E D L A Q E L L A L R S L V E L R A L L Q R P R G T S G P L E L L S E A L C S V R G P S S T V G P S L N W Y E A S D L M E L V G Q E P E S A L P D S S L S P A C S E L I G A L D S H P L S R L L W R R L K P L I L G K L L F A P D T P F T R K L M A Q V N R T F E E L T L L R D V R E V W E M L G P R I F T F M N D S S N V A M L Q R L L Q M Q D E G R R Q P R P G G R D H M E A L R S F L D P G S G G Y S W Q D A H A D V G H L V G T L G R V T E C L S L D K L E A A P S E A A L V S R A L Q L L A E H R F W A G V V F L G P E D S S D P T E H P T P D L G P G H V R I K I R M D I D V V T R T N K I R D R F W D P G P A A D P L T D L R Y V W G G F V Y L Q D L V E R A A V R V L S G A N P R A G L Y L Q Q M P Y P C Y V D D V F L R V L S R S L P L F L T L A W I Y S V T L T V K A V V R E K E T R L R D T M R A M G L S R A V L W L G W F L S C L G P F L L S A A L L V L V L K L G D I L P Y S H P G V V F L F L A A F A V A T V T Q S F L L S A F F S R A N L A A A C G G L A Y F S L Y L P Y V L C V A W R D R L P A G G R V A A S L L S P V A F G F G C E S L A L L E E Q G E G A Q W H N V G T R P T A D V F S L A Q V S G L L L L D A A L Y G L A T W Y L E A V C P G Q Y G I P E P W N F P F R R S Y W C G P R P P K S P A P C P T P L D P K V L V E E A P P G L S P G V S V R S L E K R F P G S P Q P A L R G L S L D F Y Q G H I T A F L G H N G A G K T T T L S I L S G L F P P S G G S A F I L G H D V R S S M A A I R P H L G V C P Q Y N V L F D M L T V D E H V W F Y G R L K G L S A A V V G P E Q D R L L Q D V G L V S K Q S V Q T R H L S G G M Q R K L S V A I A F V G G S Q V V I L D E P T A G V D P A S R R G I W E L L L K Y R E G R T L I L S T H H L D E A E L L G D R V A V V A G G R L C C C G S P L F L R R H L G S G Y Y L T L V K A R L P L T T N E K A D T D M E G S V D T R Q E K K N G S Q G S R V G T P Q L L A L V Q H W V P G A R L V E E L P H E L V L V L P Y T G A H D G S F A T L F R E L D T R L A E L R L T G Y G I S D T S L E E I F L K V V E E C A A D T D M E D G S C G Q H L C T G I A G L D V T L R L K M P P Q E T A L E N G E P A G S A P E T D Q G S G P D A V G R V Q G W A L T R Q Q L Q A L L L K R F L L A R R S R R G L F A Q I V L P A L F V G L A L V F S L I V P P F G H Y P A L R L S P T M Y G A Q V S F F S E D A P G D P G R A R L L E A L L Q E A G L E E P P V Q H S S H R F S A P E V P A E V A K V L A S G N W T P E S P S P A C Q C S R P G A R R L L P D C P A A A G G P P P P Q A V T G S G E V V Q N L T G R N L S D F L V K T Y P R L V R Q G L K T K K W V N E V R Y G G F S L G G R D P G L P S G Q E L G R S V E E L W A L L S P L P G G A L D R V L K N L T A W A H S L D A Q D S L K I W F N N K G W H S M V A F V N R A S N A I L R A H L P P G P A R H A H S I T T L N H P L N L T K E Q L S E G A L M A S S V D V L V S I C V V F A M S F V P A S F T L V L I E E R V T R A K H L Q L M G G L S P T L Y W L G N F L W D M C N Y L V P A C I V V L I F L A F Q Q R A Y V A P A N L P A L L L L L L L Y G W S I T P L M Y P A S F F F S V P S T A Y V V L T C I N L F I G I N G S M A T F V L E L F S D Q K L Q E V S R I L K Q V F L I F P H F C L G R G L I D M V R N Q A M A D A F E R L G D R Q F Q S P L R W E V V G K N L L A M V I Q G P L F L L F T L L L Q H R S Q L L P Q P R V R S L P L L G E E D E D V A R E R E R V V Q G A T Q G D V L V L R N L T K V Y R G Q R M P A V D R L C L G I P P G E C F G L L G V N G A G K T S T F R M V T G D T L A S R G E A V L A G H S V A R E P S A A H L S M G Y C P Q S D A I F E L L T G R E H L E L L A R L R G V P E A Q V A Q T A G S G L A R L G L S W Y A D R P A G T Y S G G N K R K L A T A L A L V G D P A V V F L D E P T T G M D P S A R R F L W N S L L A V V R E G R S V M L T S H S M E E C E A L C S R L A I M V N G R F R C L G S P Q H L K G R F A A G H T L T L R V P A A R S Q P A A A F V A A E F P G A E L R E A H G G R L R F Q L P P G G R C A L A R V F G E L A V H G A E H G V E D F S V S Q T M L E E V F L Y F S K D Q G K D E D T E E Q K E A G V G V D P A P G L Q H P K R V S Q F L D D P S T A E T V L
PTM type	X-N-glycosylation X-O-glycosylation X-Phosphorylation X-Ubiquitination X: Amino Acid

N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	312
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at ABCA7 Asparagine 312 has the potential to affect its expression or activity.
O-glycosylation
Threonine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA7			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	555
Experimental Method	Co-Immunoprecipitation
Detailed Description	O-linked Glycosylation at ABCA7 Threonine 555 has the potential to affect its expression or activity.
Phosphorylation
Serine	16 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	147
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 147 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA7			[3]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	162
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 162 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	182
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 182 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA7			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	199
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 199 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	519
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 519 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCA7			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	804
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 804 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCA7			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	934
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 934 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCA7			[7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	941
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 941 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCA7			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	949
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 949 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCA7			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	958
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 958 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCA7			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1314
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 1314 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence ABCA7			[10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1315
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 1315 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence ABCA7			[11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1342
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 1342 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence ABCA7			[12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1908
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 1908 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence ABCA7			[10], [12]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	1916
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 1916 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence ABCA7			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	2133
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Serine 2133 has the potential to affect its expression or activity.
Threonine	11 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA7			[15]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	144
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 144 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA7			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	450
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 450 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA7			[16]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	454
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 454 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA7			[17]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	580
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 580 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence ABCA7			[7]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	937
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 937 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence ABCA7			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1175
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 1175 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1405
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 1405 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1748
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 1748 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1844
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 1844 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence ABCA7			[10], [12]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1905
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 1905 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence ABCA7			[10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	1925
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Threonine 1925 has the potential to affect its expression or activity.
Tyrosine	4 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA7			[1]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	528
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Tyrosine 528 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence ABCA7			[18]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1033
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Tyrosine 1033 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence ABCA7			[18]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1034
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Tyrosine 1034 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence ABCA7			[12]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	1918
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at ABCA7 Tyrosine 1918 has the potential to affect its expression or activity.
Ubiquitination
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence ABCA7			[19]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	932
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at ABCA7 Lysine 932 has the potential to affect its expression or activity.

References
1	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: ABCA7_HUMAN)
2	Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag). Mol Cell Proteomics. 2018 Apr;17(4):764-775.
3	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
4	Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Mol Biosyst. 2013 Apr 5;9(4):732-49.
5	Protein kinase C-alpha interaction with F0F1-ATPase promotes F0F1-ATPase activity and reduces energy deficits in injured renal cells. J Biol Chem. 2015 Mar 13;290(11):7054-66.
6	Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep. 2014 Sep 11;8(5):1583-94.
7	Phosphoproteomic and Functional Analyses Reveal Sperm-specific Protein Changes Downstream of Kappa Opioid Receptor in Human Spermatozoa. Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S118-S131.
8	New opportunities for researchers in obstetrics and gynecology through programs supported by the National Institute of Child Health and Human Development. Am J Obstet Gynecol. 1999 Jul;181(1):221-5.
9	The use of NSAIDs in asthmatic children: a questionnaire survey. Paediatr Anaesth. 1999;9(4):369-70.
10	iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics. Mol Cell Proteomics. 2012 Jun;11(6):M111.014423.
11	Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells. Sci Signal. 2013 Mar 26;6(268):rs6.
12	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
13	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018 Dec 14;37(24):e99559.
14	Differential Factors in Fume Fever. Arch Bronconeumol (Engl Ed). 2019 Sep;55(9):451-452.
15	A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples. J Proteome Res. 2012 Nov 2;11(11):5311-22.
16	Fast Global Phosphoproteome Profiling of Jurkat T Cells by HIFU-TiO2-SCX-LC-MS/MS. Anal Chem. 2017 Sep 5;89(17):8853-8862.
17	TiO2 with Tandem Fractionation (TAFT): An Approach for Rapid, Deep, Reproducible, and High-Throughput Phosphoproteome Analysis. J Proteome Res. 2018 Jan 5;17(1):710-721.
18	A fast sample processing strategy for large-scale profiling of human urine phosphoproteome by mass spectrometry. Talanta. 2018 Aug 1;185:166-173.
19	New findings on essential amino acids. Cesk Fysiol. 1990;39(1):13-25.

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Detail Information of Post-Translational Modifications

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