Detail Information of Mutation-induced Spatial Variation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0533 Transporter Info | ||||
| Gene Name | ATP7B | ||||
| Transporter Name | Copper-transporting ATPase 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Mutation-induced Structural Variation (MSV) of This DT | |||||
| PDB ID | |||||
| Expression System | Homo sapiens | ||||
| Method | EM | ||||
| Resolution | 4 Å | ||||
| Corresponding chain | A | ||||
| Mutation Site(s) | C983S; C985S; D1027A | [1] | |||
| Structure Details | |||||
| Modeling Method | EM | ||||
| Publication year | 2023 | ||||
| PDB ID | |||||
| Expression System | Homo sapiens | ||||
| Method | EM | ||||
| Resolution | 3.6 Å | ||||
| Corresponding chain | A | ||||
| Mutation Site(s) | C983S; C985S; D1027A | [1] | |||
| Structure Details | |||||
| Modeling Method | EM | ||||
| Publication year | 2023 | ||||
| PDB ID | |||||
| Expression System | Homo sapiens | ||||
| Method | EM | ||||
| Resolution | 3.8 Å | ||||
| Corresponding chain | A | ||||
| Mutation Site(s) | C983S; C985S; D1027A | [1] | |||
| Structure Details | |||||
| Modeling Method | EM | ||||
| Publication year | 2023 | ||||
| PDB ID | Scanning Method | Resolution | Mutation Sites | Details | Ref |
| 2KOY | NMR | N.A. | E33A | [2] | |
| Structure | |||||
| Expression System | Escherichia coli | ||||
| 7XUN | EM | 3.4 Å | C983S; C985S; D1027A | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-1465 | Mutation | Yes | ||
| 7XUK | EM | 3.3 Å | C983S; C985S; D1027A | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-1465 | Mutation | Yes | ||
| 8IOY | EM | 4 Å | C983S; C985S; D1027A | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-1465 | Mutation | Yes | ||
| 7XUO | EM | 3.6 Å | C983S; C985S; D1027A | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-1465 | Mutation | Yes | ||
| 7XUM | EM | 3.8 Å | C983S; C985S; D1027A | [1] | |
| Structure | |||||
| Expression System | Homo sapiens | ||||
| Corresponding chain | A | ||||
| Sequence Length | 1-1465 | Mutation | Yes | ||
| References | |||||
| 1 | Structures of the human Wilson disease copper transporter ATP7B. Cell Rep. 2023;42(5):112417. | ||||
| 2 | Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of copper-transporting ATPase ATP7B. J Biol Chem. 2011 May 6;286(18):16355-62. | ||||
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