Detail Information of Mutation-induced Spatial Variation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0513 Transporter Info | ||||
| Gene Name | KCNQ1 | ||||
| Transporter Name | Voltage-gated potassium channel Kv7.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Mutation-induced Structural Variation (MSV) of This DT | |||||
| PDB ID | |||||
| Expression System | Escherichia coli | ||||
| Method | X-ray | ||||
| Resolution | 3.134 Å | ||||
| Corresponding chain | C/E | ||||
| Mutation Site(s) | K35I; A36S; P37Q; R38L; S39R; H40E; T41H; L42H; L43R; S44A; P45T; S46I; P47K; K48V; P49I; K50R; K51R; S52M; V53Q; V54Y; V55F; K56V; K57A; F60K; K61F; L62Q; D63Q; K64A; D65R | ||||
| Structure Details | |||||
| Modeling Method | X-ray | ||||
| Publication year | 2022 | ||||
| PDB ID | Scanning Method | Resolution | Mutation Sites | Details | Ref |
| 3HFC | X-ray | 2.45 Å | L602M; 606M | [1] | |
| Structure | |||||
| Expression System | Escherichia coli | ||||
| Corresponding chain | A/B/C | ||||
| Sequence Length | 583-611 | Mutation | Yes | ||
| 4UMO | X-ray | 3 Å | R397E; K398F | [2] | |
| Structure | |||||
| Expression System | Escherichia coli BL21 | ||||
| Corresponding chain | A/B | ||||
| Sequence Length | 352-539 | Mutation | Yes | ||
| 7VVH | X-ray | 2.296 Å | K35I; A36S; P37Q; R38L; S39R; H40E; T41H; L42H; L43R; S44A; P45T; S46I; P47K; K48V; P49I; K50R; K51R; S52M; V53Q; V54Y; V55F; K56V; K57A; F60K; K61F; L62Q; D63Q; K64A; D65R | ||
| Structure | |||||
| Expression System | Escherichia coli | ||||
| Corresponding chain | C | ||||
| Sequence Length | 1-149 | Mutation | Yes | ||
| 7VUO | X-ray | 2.679 Å | K35I; A36S; P37Q; R38L; S39R; H40E; T41H; L42H; L43R; S44A; P45T; S46I; P47K; K48V; P49I; K50R; K51R; S52M; V53Q; V54Y; V55F; K56V; K57A; F60K; K61F; L62Q; D63Q; K64A; D65R | ||
| Structure | |||||
| Expression System | Escherichia coli | ||||
| Corresponding chain | C | ||||
| Sequence Length | 2-149 | Mutation | Yes | ||
| 7VVD | X-ray | 3.134 Å | K35I; A36S; P37Q; R38L; S39R; H40E; T41H; L42H; L43R; S44A; P45T; S46I; P47K; K48V; P49I; K50R; K51R; S52M; V53Q; V54Y; V55F; K56V; K57A; F60K; K61F; L62Q; D63Q; K64A; D65R | ||
| Structure | |||||
| Expression System | Escherichia coli | ||||
| Corresponding chain | C/E | ||||
| Sequence Length | 1-149 | Mutation | Yes | ||
| References | |||||
| 1 | Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Sci. 2009 Oct;18(10):2100-14. | ||||
| 2 | Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin. Structure. 2014 Nov 4;22(11):1582-94. | ||||
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