Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0245 Transporter Info
Gene Name SLC28A2
Transporter Name Concentrative nucleoside transporter 2
Gene ID
9153
UniProt ID
O43868
Microbiota Influence of This DT (MBI)

Bacteria: Pseudomonadota

   Genus: Escherichia

     Escherichia coli 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC28A2 substrates/drugs in the health condition [1]

Regulating Factor
nupC

Detailed Description

 The protein nupC of Escherichia coli HB101 has been reported to transport similar substrates/drugs of SLC28A2, which affects the distribution of its substrate/drug in vivo.

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 3 Microbe Influence Related to This Species      

       Microbe Influence1

 Down regulating of SLC28A2 expression in conventional mice compared with germ-free mice [2]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Duodenum

In Vivo Model

 C57BL/6 germ-free/conventionally-raised mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC28A2.

       Microbe Influence2

 Down regulating of SLC28A2 expression in conventional mice compared with germ-free mice [3]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Ileum

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC28A2.

       Microbe Influence3

 Down regulating of SLC28A2 expression in conventional mice compared with germ-free mice [3]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Large intestine

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC28A2.
References
1 Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. Mol Membr Biol. 2004 Jan-Feb;21(1):1-10.
2 Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice. BMC Genomics. 2018 Nov 21;19(1):834.
3 RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238.

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