Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0244 Transporter Info
Gene Name SLC28A1
Transporter Name Concentrative nucleoside transporter 1
Gene ID
9154
UniProt ID
O00337
Microbiota Influence of This DT (MBI)

Bacteria: Pseudomonadota

   Genus: Escherichia

     Escherichia coli 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC28A1 substrates/drugs in the health condition [1]

Regulating Factor
nupC

Detailed Description

 The protein nupC of Escherichia coli HB101 has been reported to transport similar substrates/drugs of SLC28A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Down regulating of SLC28A1 expression in conventional mice compared with germ-free mice [2]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Ileum

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC28A1.

       Microbe Influence2

 Down regulating of SLC28A1 expression in conventional mice compared with germ-free mice [2]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Jejunum

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC28A1.
References
1 Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes. Mol Membr Biol. 2004 Jan-Feb;21(1):1-10.
2 RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238.

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