Crystal Structure of This DT
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:1-1836
Detail: Struture Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0527 Transporter Info | ||||
| Gene Name | SCN4A | ||||
| Protein Name | Voltage-gated sodium channel alpha Nav1.4 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Equus caballus (Horse) | |||||
| Gene Name | SCN4A | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6AGF_A Sequence Length:1834 Identity:89.136% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -3106.023 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-1.33 ±0.18 Residues in Favored Region:1763 Ramachandran favored:96.23% Number of Outliers:11 Ramachandran outliers:0.60% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.74 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| References | |||||
| 1 | Crystal structures of Ca(2+)-calmodulin bound to Na(V) C-terminal regions suggest role for EF-hand domain in binding and inactivation. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10763-10772. | ||||
| 2 | RCSB PDB: Veratridine binding to a transmembrane segment of mammalian sodium channel Nav1.4 determined by solid-state NMR. | ||||
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