Modelled Stucture
Method:Homology modeling
Teplate PDB:6OH4_A
Identity:91.395%
Minimized Score:-940.824
Detail: Structure Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0287 Transporter Info | ||||
| Gene Name | SLC35A1 | ||||
| Protein Name | CMP-sialic acid transporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Mus musculus (Mouse) | |||||
| Gene Name | Slc35a1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure | |||||
| Click to Save PDB File in PDB Format | |||||
| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 6OH2 | X-ray | 2.58 Å | Komagataella pastoris | [ 1] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 1-322 | Mutation | No | ||
| 6OH4 | X-ray | 3.38 Å | Komagataella pastoris | [ 1] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A/B | ||||
| Sequence Length | 1-336 | Mutation | No | ||
| 6XBO | X-ray | 1.8 Å | Komagataella pastoris | [ 2] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 1-322 | Mutation | No | ||
| Cricetulus griseus (Chinese hamster) | |||||
| Gene Name | SLC35A1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6OH4_A Sequence Length:336 Identity:95.238% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -915.223 kcal/mol | |||
| Ramachandra Favored | Excellent |
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| QMEANBrane Quality | High |
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| Ramachandran Plot |
Ramz Z Score:-0.21 ±0.41 Residues in Favored Region:332 Ramachandran favored:99.40% Number of Outliers:0 Ramachandran outliers:0.00% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.81 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| References | |||||
| 1 | Structural basis for mammalian nucleotide sugar transport. Elife. 2019 Apr 15;8:e45221. doi: 10.7554/eLife.45221. | ||||
| 2 | Inhibition of CMP-sialic acid transport by endogenous 5-methyl CMP. PLoS One. 2021;16(6):e0249905. | ||||
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