General Information of Drug Transporter (DT)
DT ID DTD0119 Transporter Info
Gene Name SLC17A6
Protein Name Vesicular glutamate transporter 2
Gene ID
57084
UniProt ID
Q9P2U8
3D Structure

Modelled Stucture

Method:Homology modeling

Teplate PDB:6V4D_A

Identity:99.607%

Minimized Score:-1083.248

Detail: Structure Info

Inter-species Structural Differences (ISD)
Mus musculus (Mouse)
        Gene Name Slc17a6
        UniProt ID
Q8BLE7
        UniProt Entry
VGLU2_MOUSE
        3D Structure

Method:Homology modeling

Teplate PDB:6V4D_A

Sequence Length:511

Identity:99.413%

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        Performance Minimized Score -1087.017 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-2.13 ±0.34

Residues in Favored Region:484

Ramachandran favored:95.09%

Number of Outliers:1

Ramachandran outliers:0.20%

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        Local Quality

QMEANBrane Score:0.78

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Rattus norvegicus (Rat)
        Gene Name Slc17a6
        UniProt ID
Q9JI12
        UniProt Entry
VGLU2_RAT
        3D Structure

Crystallisation Method:EM

Expression System:Spodoptera frugiperda

PDB ID:6V4D

Corresponding Chain:A

Sequence Length:39-547

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Danio rerio (Zebrafish)
        Gene Name slc17a6b
        UniProt ID
Q5W8I8
        UniProt Entry
VGL2A_DANRE
        3D Structure

Method:Homology modeling

Teplate PDB:6V4D_A

Sequence Length:517

Identity:88.781%

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        Performance Minimized Score -1067.227 kcal/mol
Ramachandra Favored

Medium

QMEANBrane Quality

Medium

        Ramachandran Plot

Ramz Z Score:-1.29 ±0.34

Residues in Favored Region:499

Ramachandran favored:96.89%

Number of Outliers:2

Ramachandran outliers:0.39%

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        Local Quality

QMEANBrane Score:0.78

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References
1 Ion transport and regulation in a synaptic vesicle glutamate transporter. Science. 2020 May 22;368(6493):893-897.

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