Modelled Stucture
Method:Homology modeling
Teplate PDB:2XUT_A
Identity:30.7%
Minimized Score:-615.174
Detail: Structure Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0022 Transporter Info | ||||
| Gene Name | SLC15A2 | ||||
| Protein Name | Peptide transporter 2 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Danio rerio (Zebrafish) | |||||
| Gene Name | slc15a2 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:2XUT_A Sequence Length:359 Identity:31.605% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -573.268 kcal/mol | |||
| Ramachandra Favored | Poor |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-2.33 ±0.4 Residues in Favored Region:333 Ramachandran favored:93.28% Number of Outliers:5 Ramachandran outliers:1.40% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.74 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| References | |||||
| 1 | Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport. Structure. 2015 Oct 6;23(10):1889-1899. | ||||
| 2 | Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. Sci Adv. 2021;7(35). | ||||
| 3 | Structural basis for antibiotic transport and inhibition in PepT2. Nat Commun. 2024;15(1):8755. | ||||
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