Modelled Stucture
Method:Homology modeling
Teplate PDB:6UY0_A
Identity:90.725%
Minimized Score:-3891.081
Detail: Structure Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0001 Transporter Info | ||||
| Gene Name | ABCC1 | ||||
| Protein Name | Multidrug resistance-associated protein 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Macaca fascicularis (Cynomolgus monkey) | |||||
| Gene Name | ABCC1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UY0_A Sequence Length:1531 Identity:90.79% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -3673.677 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.85 ±0.19 Residues in Favored Region:1498 Ramachandran favored:97.97% Number of Outliers:7 Ramachandran outliers:0.46% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.78 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Gallus gallus (Chicken) | |||||
| Gene Name | ABCC1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UY0_A Sequence Length:1524 Identity:78.968% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -3514.198 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.48 ±0.2 Residues in Favored Region:1490 Ramachandran favored:97.90% Number of Outliers:7 Ramachandran outliers:0.46% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.78 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| Bos taurus (Bovine) | |||||
| Gene Name | ABCC1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure | |||||
| Click to Save PDB File in PDB Format | |||||
| Experimental Structures of This Model Oganism | |||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref |
| 5UJ9 | EM | 3.49 Å | Homo sapiens | [ 1] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 205-1530 | Mutation | No | ||
| 5UJA | EM | 3.34 Å | Homo sapiens | [ 1] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 205-1530 | Mutation | No | ||
| 6BHU | EM | 3.14 Å | Homo sapiens | [ 2] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 1-1530 | Mutation | Yes | ||
| 8F4B | EM | 3.27 Å | Homo sapiens,Synthetic construct | [ 3] | |
| Structure | |||||
| Click to Save PDB File in TXT Format | |||||
| Corresponding chain | A | ||||
| Sequence Length | 205-1530 | Mutation | No | ||
| References | |||||
| 1 | Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1. Cell. 2017 Mar 9;168(6):1075-1085.e9. | ||||
| 2 | ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1. Cell. 2018 Jan 11;172(1-2):81-89.e10. | ||||
| 3 | A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Proc Natl Acad Sci U S A. 2023;120(11):e2220012120. | ||||
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