Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0505 Transporter Info | ||||
| Gene Name | SLCO6A1 | ||||
| Protein Name | Organic anion-transporting polypeptide 6A1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs7734060 | ||||
| Site of GPD | chr5:102444775 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>G | ||||
| Minor Allele Frequency | G=0.1767/885 (Global) | ||||
| Allele G | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| N.A. | N.A. | Major depressive disorder | Correlated with the risk locus for major depressive disorder in the Han Chinese population (compare with wide type) | [ 1] | |
| Genetic Polymorphism | rs6878284 | ||||
| Site of GPD | chr5:102434022 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | C>T | ||||
| Minor Allele Frequency | C=0.3007/1347 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| N.A. | N.A. | Schizophrenia | Irrelevant to the risk of schizophrenia (compare with wide type) | [ 1] | |
| Genetic Polymorphism | rs12658397 | ||||
| Site of GPD | chr5:102415949 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | T>C | ||||
| Minor Allele Frequency | T=0.7350/1454 (Global) | ||||
| Allele C | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Daunorubicin | N.A. | Cardiotoxicity | Allele C is associated with increased likelihood of cardiotoxicity when treated with daunorubicin or doxorubicin in children with Neoplasms as compared to allele T. | [ 2] | |
| Doxorubicin | N.A. | Cardiotoxicity | Allele C is associated with increased likelihood of cardiotoxicity when treated with daunorubicin or doxorubicin in children with Neoplasms as compared to allele T. | [ 2] | |
| References | |||||
| 1 | Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population. World J Biol Psychiatry. 2016;17(2):140-6. | ||||
| 2 | Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. Pharmacogenomics. 2015;16(10):1065-76. | ||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.