General Information of Drug Transporter (DT)
DT ID	DTD0494 Transporter Info
Gene Name	SLC9A9
Protein Name	Sodium/hydrogen exchanger 9
Gene ID	285195
UniProt ID	Q8IVB4
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs9828519
Site of GPD	chr3:143707136 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	G>A / G>C / G>T
Minor Allele Frequency	G=0.3150/1168 (Global)
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Interferon-beta	N.A.	Multiple sclerosis	Correlated with the significantly regulated transporter expression only in occipital cortex, intralobular white matter, and substantia nigra (compare with wide type)		[ 1]
Genetic Polymorphism	rs4839603
Site of GPD	chr3:143592418 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	A>G
Minor Allele Frequency	A=0.7740/1531 (Global)
Genotype GG	Click to Show/Hide the Full List of Affected Drugs:           2 Drugs in Total
Fentanyl	N.A.	Multiple Myeloma	Genotype GG is associated with decreased dose of fentanyl or remifentanil in people with Pain as compared to genotypes AA + AG.		[ 2]
Remifentanil	N.A.	Multiple Myeloma	Genotype GG is associated with decreased dose of fentanyl or remifentanil in people with Pain as compared to genotypes AA + AG.		[ 2]
References
1	Genetic Variants and Multiple Sclerosis Risk Gene SLC9A9 Expression in Distinct Human Brain Regions. Mol Neurobiol. 2017 Nov;54(9):6820-6826.
2	Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy. Pharmacogenomics. 2018 Jan;19(2):113-127.

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