Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0021 Transporter Info | ||||
| Gene Name | SLC15A1 | ||||
| Protein Name | Peptide transporter 1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs8001466 | ||||
| Site of GPD | chr13:98703347 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | G>C / G>T | ||||
| Minor Allele Frequency | G=0.7380/1460 (Global) | ||||
| Allele G | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Daunorubicin | N.A. | Cardiotoxicity | Allele G is associated with increased likelihood of cardiotoxicity when treated with daunorubicin or doxorubicin in children with Neoplasms as compared to allele C. | [ 1] | |
| Doxorubicin | N.A. | Cardiotoxicity | Allele G is associated with increased likelihood of cardiotoxicity when treated with daunorubicin or doxorubicin in children with Neoplasms as compared to allele C. | [ 1] | |
| Genetic Polymorphism | rs1339067 | ||||
| Site of GPD | chr13:98704358 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | A>C / A>G / A>T | ||||
| Minor Allele Frequency | A=0.3560/704 (Global) | ||||
| Genotype TT | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Cannabidiol | N.A. | Cardiotoxicity | Genotype TT is associated with decreased response to cannabidiol in people with Epilepsy as compared to genotypes AA + AT. | [ 2] | |
| References | |||||
| 1 | Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. Pharmacogenomics. 2015;16(10):1065-76. | ||||
| 2 | Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy. Clin Pharmacol Ther. 2021 Nov;110(5):1368-1380. | ||||
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