Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0546 Transporter Info
Gene Name KCNK9
Transporter Name Potassium channel subfamily K member 9
Gene ID
51305
UniProt ID
Q9NPC2
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  4-O-methyl-12-O-tetradecanoylphorbol 13-acetate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction KCNK9 protein results in increased transport of Potassium [7]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of KCNK9 promoter [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene results in increased methylation of KCNK9 5' UTR [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Benzo(a)pyrene results in increased methylation of KCNK9 exon [8]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A co-treated with Fulvestrant results in decreased methylation of KCNK9 gene [9]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 bisphenol A results in decreased methylation of KCNK9 gene [9]

Regulation Mechanism

 Transcription Factor Info

  Bupivacaine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bupivacaine inhibits the reaction KCNK9 protein results in increased transport of Potassium [10]

Regulation Mechanism

 Transcription Factor Info

  butyraldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 butyraldehyde results in increased expression of KCNK9 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  ethyl-p-hydroxybenzoate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ethyl-p-hydroxybenzoate results in increased expression of KCNK9 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  Fonofos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fonofos results in increased methylation of KCNK9 promoter [12]

Regulation Mechanism

 Transcription Factor Info

  Fulvestrant

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A co-treated with Fulvestrant results in decreased methylation of KCNK9 gene [9]

Regulation Mechanism

 Transcription Factor Info

  Halothane

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Halothane promotes the reaction KCNK9 protein results in increased transport of Potassium [10]

Regulation Mechanism

 Transcription Factor Info

  Methyl Methanesulfonate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyl Methanesulfonate results in increased expression of KCNK9 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  NSC 689534

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 NSC 689534 results in increased expression of KCNK9 mRNA [5]

Regulation Mechanism

 Transcription Factor Info

  Parathion

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Parathion results in increased methylation of KCNK9 promoter [12]

Regulation Mechanism

 Transcription Factor Info

  Potassium

            7 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction KCNK9 protein results in increased transport of Potassium [7]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Bupivacaine inhibits the reaction KCNK9 protein results in increased transport of Potassium [10]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Halothane promotes the reaction KCNK9 protein results in increased transport of Potassium [10]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 KCNK3 protein binds to KCNK9 protein which results in increased transport of Potassium [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 KCNK9 protein results in increased transport of Potassium [10]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 sanshool inhibits the reaction KCNK3 protein binds to KCNK9 protein which results in increased transport of Potassium [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 sanshool inhibits the reaction KCNK9 protein results in increased transport of Potassium [14]

Regulation Mechanism

 Transcription Factor Info

  sanshool

            5 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 KCNK9 protein affects the susceptibility to sanshool [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 sanshool inhibits the reaction KCNK3 protein binds to KCNK9 protein which results in increased transport of Potassium [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 sanshool inhibits the reaction KCNK9 protein results in increased transport of Potassium [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 sanshool results in decreased activity of KCNK3 protein binds to KCNK9 protein [14]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 sanshool results in decreased activity of KCNK9 protein [14]

Regulation Mechanism

 Transcription Factor Info

  terbufos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 terbufos results in increased methylation of KCNK9 promoter [12]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Fluoxetine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fluoxetine inhibits the activity of KCNK9 [1]

Cell System

 Human embryonic kidney 293 cells (HEK293)-KCNK9

  Calcitriol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Calcitriol increases the expression of KCNK9 [2]

  Methotrexate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methotrexate inhibits the expression of KCNK9 [3]

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of KCNK9 [4]

Patented Pharmaceutical Agent

  NSC-689534

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 NSC-689534 increases the expression of KCNK9 [5]

Health and Environmental Toxicant

  Butyraldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Butyraldehyde increases the expression of KCNK9 [6]
References
1 Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem. 2016 Jun 9;59(11):5149-57.
2 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
3 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
4 Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
5 A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.
6 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
7 KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. J Neurophysiol. 2001;86(1):130-42.
8 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
9 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
10 Functional characterisation of human TASK-3, an acid-sensitive two-pore domain potassium channel. Neuropharmacology. 2001;40(4):551-9.
11 Risk assessment of parabens in a transcriptomics-based in vitro test. Chem Biol Interact. 2023;384:110699.
12 DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.
13 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
14 Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci. 2008;11(7):772-9.

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