Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0514 Transporter Info
Gene Name	ANXA11
Transporter Name	Annexin A11
Gene ID	311
UniProt ID	P50995

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of ANXA11 intron		[25]
Regulation Mechanism			Transcription Factor Info
Carcinogen
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of ANXA11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of ANXA11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ANXA11 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ANXA11 protein		[23]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in decreased expression of ANXA11 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of ANXA11		[1]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ANXA11		[2]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of ANXA11		[3]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine inhibits the expression of ANXA11		[4]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of ANXA11		[5]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of ANXA11		[6]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ANXA11		[7]
Drug in Phase 3 Trial
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the expression of ANXA11		[8]
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the expression of ANXA11		[4]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of ANXA11		[14]
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of ANXA11		[16]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of ANXA11		[18]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of ANXA11		[18]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of ANXA11		[11]
Investigative Drug
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of ANXA11		[13]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution affects the expression of ANXA11		[17]
Environmental toxicant
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol F increases the expression of ANXA11		[18]
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of ANXA11		[19]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of ANXA11		[15]
Health and Environmental Toxicant
Lithium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lithium Chloride increases the expression of ANXA11		[9]
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of ANXA11		[10]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of ANXA11		[12]
Chemical Compound
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of ANXA11 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pentanal inhibits the expression of ANXA11		[12]
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ANXA11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of ANXA11 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ANXA11 protein		[21]
Regulation Mechanism			Transcription Factor Info
2-amino-14,16-dimethyloctadecan-3-ol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-amino-14,16-dimethyloctadecan-3-ol results in decreased expression of ANXA11 protein		[22]
Regulation Mechanism			Transcription Factor Info
2-bromopalmitate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ANXA11 protein		[23]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
4-aminophenylarsenoxide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-aminophenylarsenoxide binds to ANXA11 protein		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Arsenic Trioxide inhibits the reaction 4-aminophenylarsenoxide binds to ANXA11 protein		[24]
Regulation Mechanism			Transcription Factor Info
Aldehydes	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aldehydes results in decreased expression of ANXA11 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the reaction 4-aminophenylarsenoxide binds to ANXA11 protein		[24]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of ANXA11 3' UTR		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of ANXA11 5' UTR		[28]
Regulation Mechanism			Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of ANXA11 protein		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased methylation of ANXA11 gene		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Phenolsulfonphthalein deficiency co-treated with bisphenol A deficiency results in increased expression of ANXA11 protein		[30]
Regulation Mechanism			Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of ANXA11 protein		[18]
Regulation Mechanism			Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of ANXA11 protein		[18]
Regulation Mechanism			Transcription Factor Info
bisphenol F	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol F results in increased expression of ANXA11 protein		[18]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ANXA11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased expression of ANXA11 protein		[18]
Regulation Mechanism			Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of ANXA11 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ANXA11 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ANXA11 protein		[23]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased expression of ANXA11 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased expression of ANXA11 protein		[32]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of ANXA11 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
decabromobiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	decabromobiphenyl ether results in decreased expression of ANXA11 protein		[21]
Regulation Mechanism			Transcription Factor Info
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ANXA11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of ANXA11 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of ANXA11 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate results in decreased expression of ANXA11 protein		[4]
Regulation Mechanism			Transcription Factor Info
Furaldehyde	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of ANXA11 protein		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in decreased expression of ANXA11 protein		[34]
Regulation Mechanism			Transcription Factor Info
Gasoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of ANXA11 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ANXA11 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
isobutyl alcohol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of ANXA11 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of ANXA11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of ANXA11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ANXA11 protein affects the susceptibility to Methotrexate		[36]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of ANXA11 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pentanal results in decreased expression of ANXA11 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Phenolsulfonphthalein	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenolsulfonphthalein deficiency co-treated with bisphenol A deficiency results in increased expression of ANXA11 protein		[30]
Regulation Mechanism			Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in decreased expression of ANXA11 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of ANXA11 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in decreased expression of ANXA11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of ANXA11 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Sodium Chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of ANXA11 protein		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with Furaldehyde results in decreased expression of ANXA11 protein		[34]
Regulation Mechanism			Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in increased expression of ANXA11 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in increased expression of ANXA11 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of ANXA11 mRNA		[11]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ANXA11 mRNA		[41]
Regulation Mechanism			Transcription Factor Info

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Detail Information of Exogenous Modulation

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