Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0213 Transporter Info
Gene Name SLC25A5
Transporter Name Adenine nucleotide translocator 2
Gene ID
292
UniProt ID
P05141
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Doxorubicin affects the expression of SLC25A5 protein [28]

Regulation Mechanism

 Transcription Factor Info

  1-Methyl-4-phenylpyridinium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A5 protein [5]

Regulation Mechanism

 Transcription Factor Info

  Acrolein

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  alpha-pinene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  Atractyloside

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atractyloside results in decreased activity of SLC25A5 protein [21]

Regulation Mechanism

 Transcription Factor Info

  azoxystrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 azoxystrobin results in increased expression of SLC25A5 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene results in increased methylation of SLC25A5 promoter [22]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A affects the expression of SLC25A5 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 bisphenol A results in decreased expression of SLC25A5 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 bisphenol A results in increased expression of SLC25A5 protein [24]

Regulation Mechanism

 Transcription Factor Info

  Bongkrekic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bongkrekic Acid results in decreased activity of SLC25A5 protein [21]

Regulation Mechanism

 Transcription Factor Info

  carboxyatractyloside

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 carboxyatractyloside results in decreased activity of SLC25A5 protein [21]

Regulation Mechanism

 Transcription Factor Info

  CD 437

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CD 437 results in decreased activity of SLC25A5 protein [21]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 CD 437 results in decreased expression of SLC25A5 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 chloropicrin affects the expression of SLC25A5 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  closantel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 closantel results in decreased activity of SLC25A5 protein [21]

Regulation Mechanism

 Transcription Factor Info

  corosolic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 corosolic acid results in decreased expression of SLC25A5 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  Dactinomycin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dactinomycin co-treated with nutlin 3 results in increased secretion of SLC25A5 protein [26]

Regulation Mechanism

 Transcription Factor Info

  dehydroabietylamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 dehydroabietylamine results in increased activity of SLC25A5 protein [21]

Regulation Mechanism

 Transcription Factor Info

  Dinitrochlorobenzene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dinitrochlorobenzene binds to SLC25A5 protein [27]

Regulation Mechanism

 Transcription Factor Info

  Fonofos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fonofos results in increased methylation of SLC25A5 promoter [29]

Regulation Mechanism

 Transcription Factor Info

  FR900359

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 FR900359 results in increased phosphorylation of SLC25A5 protein [30]

Regulation Mechanism

 Transcription Factor Info

  Hydralazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Hydralazine co-treated with Valproic Acid results in increased expression of SLC25A5 mRNA [31]

Regulation Mechanism

 Transcription Factor Info

  ICG 001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG 001 results in decreased expression of SLC25A5 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

  Isoniazid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Isoniazid results in increased expression of SLC25A5 protein [32]

Regulation Mechanism

 Transcription Factor Info

  K 7174

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 K 7174 results in increased expression of SLC25A5 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  methacrylaldehyde

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  nutlin 3

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dactinomycin co-treated with nutlin 3 results in increased secretion of SLC25A5 protein [26]

Regulation Mechanism

 Transcription Factor Info

  oxophenylarsine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 oxophenylarsine results in decreased activity of SLC25A5 protein [33]

Regulation Mechanism

 Transcription Factor Info

  Ozone

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Volatile Organic Compounds co-treated with Ozone results in increased oxidation of SLC25A5 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  Parathion

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Parathion results in increased methylation of SLC25A5 promoter [29]

Regulation Mechanism

 Transcription Factor Info

  picoxystrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 picoxystrobin results in increased expression of SLC25A5 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  pyrachlostrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pyrachlostrobin results in increased expression of SLC25A5 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  pyrimidifen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pyrimidifen results in increased expression of SLC25A5 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of SLC25A5 mRNA [34]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 sodium arsenite results in increased expression of SLC25A5 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  Sodium Selenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium Selenite results in increased expression of SLC25A5 mRNA [35]

Regulation Mechanism

 Transcription Factor Info

  terbufos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 terbufos results in increased methylation of SLC25A5 promoter [29]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC25A5 mRNA [36]

Regulation Mechanism

 Transcription Factor Info

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Hydralazine co-treated with Valproic Acid results in increased expression of SLC25A5 mRNA [31]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Valproic Acid results in increased methylation of SLC25A5 gene [37]

Regulation Mechanism

 Transcription Factor Info

  Vitamin K 3

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vitamin K 3 affects the expression of SLC25A5 mRNA [3]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Ursodeoxycholic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ursodeoxycholic Acid affects the expression of SLC25A5 [1]

  Copper Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate inhibits the expression of SLC25A5 [2]

  Menadione

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Menadione affects the expression of SLC25A5 [3]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of SLC25A5 [4]

  Dopamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dopamine increases the expression of SLC25A5 [5]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen increases the expression of SLC25A5 [6]

  Doxorubicin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin increases the expression of SLC25A5 [7]

  Ivermectin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ivermectin inhibits the expression of SLC25A5 [8]

Drug Marketed but not Approved by US FDA

  Rotenone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rotenone increases the expression of SLC25A5 [9]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A inhibits the expression of SLC25A5 [18]

Drug in Phase 1 Trial

  Sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium arsenite increases the expression of SLC25A5 [19]

Patented Pharmaceutical Agent

  K-7174

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 K-7174 increases the expression of SLC25A5 [13]

  ICG-001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG-001 inhibits the expression of SLC25A5 [15]

Natural Product

  Coal Ash

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Coal Ash inhibits the expression of SLC25A5 [11]

Mycotoxins

  Aflatoxin B1

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 increases the expression of SLC25A5 [17]

  DT Modulation2

 Aflatoxin B1 results in decreased methylation of SLC25A5 gene [17]

Regulation Mechanism

 Transcription Factor Info

Acute Toxic Substance

  Cadmium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium inhibits the expression of SLC25A5 [14]

  Chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Chloropicrin affects the expression of SLC25A5 [16]

Fungicide

  Azoxystrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Azoxystrobin increases the expression of SLC25A5 [9]

Health and Environmental Toxicant

  CD-437

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CD-437 inhibits the expression of SLC25A5 [10]

  1-methyl-4-phenylpyridinium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-methyl-4-phenylpyridinium increases the expression of SLC25A5 [5]

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine increases the expression of SLC25A5 [12]
References
1 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010.
2 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203.
4 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
5 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
6 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
7 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
8 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
9 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615.
10 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
11 Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.
12 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
13 A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
14 Using expression profiling to understand the effects of chronic cadmium exposure on MCF-7 breast cancer cells. PLoS One. 2013 Dec 20;8(12):e84646.
15 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
16 Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
17 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
18 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
19 Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer. Arch Toxicol. 2021 Jul;95(7):2351-2365.
20 Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
21 Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast. J Biomol Screen. 2016 Apr;21(4):381-90.
22 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
23 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134.
24 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101.
25 Quantitative transcriptomic and proteomic analysis reveals corosolic acid inhibiting bladder cancer via suppressing cell cycle and inducing mitophagy in vitro and in vivo. Toxicol Appl Pharmacol. 2023;480:116749.
26 Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes. Chem Biol Interact. 2024;392:110946.
27 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020;445:152603.
28 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018;163(1):182-195.
29 DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.
30 Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
31 A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer. PLoS One. 2006;1(1):e98.
32 Endoplasmic reticulum stress inhibition preserves mitochondrial function and cell survival during the early onset of isoniazid-induced oxidative stress. Chem Biol Interact. 2025;411:111448.
33 The spirostenol (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate blocks mitochondrial uptake of Abeta in neuronal cells and prevents Abeta-induced impairment of mitochondrial function. Steroids. 2006;71(8):725-35.
34 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
35 Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. Am J Clin Nutr. 2008;87(1):181-9.
36 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
37 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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