Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0193 Transporter Info
Gene Name SLC25A31
Transporter Name Adenine nucleotide translocator 4
Gene ID
83447
UniProt ID
Q9H0C2
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC25A31 promoter [5]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene results in increased mutagenesis of SLC25A31 gene [6]

Regulation Mechanism

 Transcription Factor Info

  CD 437

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CD 437 results in decreased activity of SLC25A31 protein [4]

Regulation Mechanism

 Transcription Factor Info

  closantel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 closantel results in decreased activity of SLC25A31 protein [4]

Regulation Mechanism

 Transcription Factor Info

  dehydroabietylamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 dehydroabietylamine affects the activity of SLC25A31 protein [4]

Regulation Mechanism

 Transcription Factor Info

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid results in increased methylation of SLC25A31 gene [7]

Regulation Mechanism

 Transcription Factor Info

Investigative Drug

  2,2'-Methanediylbis (4-nitrophenol)

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2,2'-Methanediylbis(4-nitrophenol) inhibits the activity of SLC25A31 (IC50 = 1.4 microM) [1]

Cell System

 Meiotic germ cells

Carcinogen

  Benzo(a)pyrene

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene increases the expression of SLC25A31 [2]

Health and Environmental Toxicant

  CD-437

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CD-437 inhibits the activity of SLC25A31 [4]

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine increases the expression of SLC25A31 [3]
References
1 Identification of adenine nucleotide translocase 4 inhibitors by molecular docking. J Mol Graph Model. 2013 Sep;45:173-9.
2 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
3 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
4 Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast. J Biomol Screen. 2016 Apr;21(4):381-90.
5 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
6 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014;775-776:48-54.
7 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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