Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0021 Transporter Info
Gene Name	SLC15A1
Transporter Name	Peptide transporter 1
Gene ID	6564
UniProt ID	P46059

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Zinc results in decreased activity of SLC15A1 protein which results in decreased uptake of Ceftibuten			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Zinc results in decreased activity of SLC15A1 protein which results in decreased uptake of Cephradine			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fosinopril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fluvastatin results in decreased activity of SLC15A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fluorouracil results in decreased activity of SLC15A1 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Quinapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Zinc inhibits the reaction JBP 485 binds to SLC15A1 protein			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zinc inhibits the reaction JBP 485 binds to SLC15A1 protein which results in decreased uptake of JBP 485			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Zinc results in decreased activity of SLC15A1 protein			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Zinc results in decreased activity of SLC15A1 protein which results in decreased uptake of Ceftibuten			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Zinc results in decreased activity of SLC15A1 protein which results in decreased uptake of Cephradine			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Zinc results in decreased activity of SLC15A1 protein which results in decreased uptake of glycylsarcosine			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Aspartame results in decreased activity of SLC15A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	AICA ribonucleotide results in decreased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC15A1 exon			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC15A1 promoter			[43]
Regulation Mechanism				Transcription Factor Info
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SLC15A1 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
benazepril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benazepril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of SLC15A1 intron			[44]
Regulation Mechanism				Transcription Factor Info
Benzoic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzoic Acid analog binds to SLC15A1 protein			[45]
Regulation Mechanism				Transcription Factor Info
Cilazapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cilazapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC15A1 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Fonofos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fonofos results in increased methylation of SLC15A1 promoter			[47]
Regulation Mechanism				Transcription Factor Info
glycylsarcosine	16 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benazepril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cilazapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Fosinopril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	glycylsarcosine inhibits the reaction SLC15A1 protein results in increased transport of Lisdexamfetamine Dimesylate			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	glycylsarcosine results in decreased activity of SLC15A1 protein			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	moexipril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Perindopril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	quinaprilat inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Quinapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Ramipril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	SLC15A1 protein results in increased transport of glycylsarcosine			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	spirapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	trandolapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Valganciclovir inhibits the reaction SLC15A1 protein results in increased transport of glycylsarcosine			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Zinc results in decreased activity of SLC15A1 protein which results in decreased uptake of glycylsarcosine			[33]
Regulation Mechanism				Transcription Factor Info
JBP 485	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	JBP 485 binds to and results in decreased activity of SLC15A1 protein			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zinc inhibits the reaction JBP 485 binds to SLC15A1 protein			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Zinc inhibits the reaction JBP 485 binds to SLC15A1 protein which results in decreased uptake of JBP 485			[50]
Regulation Mechanism				Transcription Factor Info
Lactic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lactic Acid results in decreased expression of SLC15A1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
Lisdexamfetamine Dimesylate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glycylsarcosine inhibits the reaction SLC15A1 protein results in increased transport of Lisdexamfetamine Dimesylate			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC15A1 protein results in increased transport of Lisdexamfetamine Dimesylate			[48]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of SLC15A1 intron			[44]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC15A1 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
mifobate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mifobate inhibits the reaction Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
moexipril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	moexipril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in decreased expression of SLC15A1 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC15A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Parathion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Parathion results in increased methylation of SLC15A1 promoter			[47]
Regulation Mechanism				Transcription Factor Info
Perindopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perindopril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
phenylalanylserine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	phenylalanylserine analog binds to SLC15A1 protein			[45]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of SLC15A1 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pirinixic acid results in increased expression of SLC15A1 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC15A1 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
quinaprilat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quinaprilat inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
Ramipril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ramipril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
repaglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	repaglinide results in decreased activity of SLC15A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
Rosiglitazone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the reaction Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	mifobate inhibits the reaction Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sirolimus inhibits the reaction Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
Sirolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sirolimus inhibits the reaction Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
spirapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	spirapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
terbufos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terbufos results in increased methylation of SLC15A1 promoter			[47]
Regulation Mechanism				Transcription Factor Info
trandolapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trandolapril inhibits the reaction SLC15A1 protein results in increased uptake of glycylsarcosine			[42]
Regulation Mechanism				Transcription Factor Info
Triiodothyronine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the reaction Triiodothyronine results in decreased expression of SLC15A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction Triiodothyronine results in decreased expression of SLC15A1 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Triiodothyronine results in decreased expression of SLC15A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Triiodothyronine results in decreased expression of SLC15A1 protein			[25]
Regulation Mechanism				Transcription Factor Info
Valganciclovir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC15A1 protein results in increased transport of Valganciclovir			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valganciclovir inhibits the reaction SLC15A1 protein results in increased transport of glycylsarcosine			[49]
Regulation Mechanism				Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadium results in decreased expression of SLC15A1 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Valacyclovir	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valacyclovir inhibits the transportation of Cefadroxil by SLC15A1 (Ki = 910 microM)			[1]
Affected Drug/Substrate	Cefadroxil	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
DT Modulation2	Valacyclovir inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 1280 microM)			[1]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
DT Modulation3	Valacyclovir inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 4080 microM)			[3]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Oocytes-PEPT1
DT Modulation4	Valacyclovir inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 400 microM)			[6]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
Cefixime	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefixime inhibits the transportation of Cefadroxil by SLC15A1 (Ki = 1310 microM)			[2]
Affected Drug/Substrate	Cefadroxil	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cefixime inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 10000 microM)			[5]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation3	Cefixime inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 12000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation4	Cefixime inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cyclacillin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclacillin inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 600 microM)			[4]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cyclacillin inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 350 microM)			[4]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-PEPT1
DT Modulation3	Cyclacillin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 500 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation4	Cyclacillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Ceftibuten	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftibuten inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 870 microM)			[5]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Ceftibuten inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 710 microM)			[5]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-PEPT1
DT Modulation3	Ceftibuten inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 340 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation4	Ceftibuten inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Ampicillin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ampicillin inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 10000 microM)			[9]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
DT Modulation2	Ampicillin inhibits the transportation of Valacyclovir by SLC15A1			[1]
Affected Drug/Substrate	Valacyclovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
DT Modulation3	Ampicillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefuroxime	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefuroxime inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 26000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cefuroxime inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki > 5000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation3	Cefuroxime inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Losartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 52 microM)			[10]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-PEPT1
DT Modulation2	Losartan inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 24 microM)			[10]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Valsartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valsartan inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 560 microM)			[10]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-PEPT1
DT Modulation2	Valsartan inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 390 microM)			[10]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefamandole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 8100 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cefamandole inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefmetazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefmetazole inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 28000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cefmetazole inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cephapirin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephapirin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki > 10000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cephapirin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cephradine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephradine inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 9.8 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cephradine inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cloxacillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cloxacillin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 3000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Cloxacillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Dicloxacillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicloxacillin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 7200 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Dicloxacillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Moxalactam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Moxalactam inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 12300 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Moxalactam inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Oxacillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxacillin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 12000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Oxacillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefadroxil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Glycylsarcosine by SLC15A1			[11]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-PEPT1
DT Modulation2	Cefadroxil inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Irbesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 230 microM)			[10]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Levodopa	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levodopa inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 141200 microM)			[12]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
Methyldopa	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyldopa inhibits the transportation of Glycylsarcosine by SLC15A1 (IC50 = 151600 microM)			[12]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-PEPT1
Fosinopril	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fosinopril inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 35.5 microM)			[13]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefsulodin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefsulodin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki > 30000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Ceftazidime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftazidime inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki > 10000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Bestatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bestatin inhibits the transporation of melatonin by SLC15A1 (IC50 = 1000 microM)			[14]
Affected Drug/Substrate	Melatonin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)
Loracarbef	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loracarbef inhibits the transportation of Cefadroxil by SLC15A1			[2]
Affected Drug/Substrate	Cefadroxil	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefdinir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefdinir inhibits the transportation of Glycylsarcosine by SLC15A1			[5]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-PEPT1
Captopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Captopril inhibits the transportation of Sulpiride by SLC15A1			[15]
Affected Drug/Substrate	Sulpiride	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefaclor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefaclor inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefazolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefazolin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefepime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefepime inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefotaxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotaxime inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefoxitin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoxitin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cefpodoxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefpodoxime inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Ceftriaxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftriaxone inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cephalexin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalexin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Cephalothin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalothin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Floxacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flucloxacillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Penicillin V	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Penicillin V inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Piperacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperacillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Azathioprine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azathioprine inhibits the expression of SLC15A1			[16]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the expression of SLC15A1			[17]
Fluvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the activity of SLC15A1			[18]
Repaglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Repaglinide inhibits the activity of SLC15A1			[18]
Fluorouracil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorouracil inhibits the expression of SLC15A1			[19]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC15A1			[20]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC15A1			[21]
Metformin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin increases the expression of SLC15A1			[22]
DT Modulation2	Metformin inhibits the reaction Rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Metformin results in decreased activity of and results in decreased expression of SLC15A1 protein			[22]
Regulation Mechanism				Transcription Factor Info
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC15A1			[23]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid affects the expression of SLC15A1			[24]
Liothyronine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Liothyronine inhibits the expression of SLC15A1			[25]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC15A1			[26]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC15A1			[27]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC15A1			[28]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin induces the activity of SLC15A1			[19]
Quinapril	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinapril inhibits the activity of SLC15A1			[29]
Insulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Insulin induces the activity of SLC15A1			[30]
Enalapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enalapril inhibits the activity of SLC15A1			[31]
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen analog binds to SLC15A1 protein			[45]
Regulation Mechanism				Transcription Factor Info
Drug in Phase 3 Trial
Benzylpenicillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin inhibits the transportation of Glycylsarcosine by SLC15A1 (Ki = 30000 microM)			[7]
Affected Drug/Substrate	Glycylsarcosine	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
DT Modulation2	Benzylpenicillin inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Resveratrol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of SLC15A1			[32]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human colon adenocarcinoma cells (Caco-2)
Drug in Phase 2 Trial
MeIQx	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MeIQx inhibits the expression of SLC15A1			[35]
Drug in Phase 1 Trial
Aspartame	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspartame inhibits the activity of SLC15A1			[18]
AICA ribonucleotide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AICA ribonucleotide inhibits the activity of SLC15A1			[22]
Discontinued Drug
MDL-28170	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MDL-28170 inhibits the activity of SLC15A1			[8]
Cell System	Human enterocyte-like 2 cell (Caco-2)-PEPT1
Investigative Drug
Milchsaure	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Milchsaure inhibits the expression of SLC15A1			[36]
4-AMBA	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-AMBA inhibits the activity of SLC15A1			[39], [40]
[11C]GlySar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	[11C]GlySar modulates the activity of SLC15A1			[41]
[14C]GlySar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	[14C]GlySar modulates the activity of SLC15A1			[41]
[3H]GlySar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	[3H]GlySar modulates the activity of SLC15A1			[41]
Natural Product
DT Modulation1	Resveratrol inhibits the reaction Triiodothyronine results in decreased expression of SLC15A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction Triiodothyronine results in decreased expression of SLC15A1 protein			[25]
Regulation Mechanism				Transcription Factor Info
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC15A1			[37]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution affects the expression of SLC15A1			[38]
Environmental toxicant
Zinc	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc inhibits the activity of SLC15A1			[33]
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 affects the expression of SLC15A1			[20]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC15A1			[37]
Health and Environmental Toxicant
Pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pirinixic acid increases the expression of SLC15A1			[34]

References
1	Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line. J Pharmacol Exp Ther. 1999 Apr;289(1):448-54.
2	Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells. J Pharmacol Exp Ther. 1996 May;277(2):831-9.
3	Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir. Biochem Biophys Res Commun. 1998 Sep 18;250(2):246-51.
4	Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J Biol Chem. 1995 Oct 27;270(43):25672-7.
5	Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2. Biochim Biophys Acta. 1997 Mar 13;1324(2):296-308.
6	5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res. 1998 Aug;15(8):1154-9.
7	Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24.
8	Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9.
9	Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells. Pharm Res. 1996 Nov;13(11):1631-4.
10	High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9.
11	Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem. 1995 Mar 24;270(12):6456-63.
12	CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. J Pharm Sci. 1999 Mar;88(3):347-50.
13	Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos. 2001 Oct;29(10):1307-15.
14	Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential. J Pineal Res. 2017 May;62(4).
15	Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2. Biol Pharm Bull. 2002 Jul;25(7):885-90.
16	Severe villus atrophy and chronic malabsorption induced by azathioprine. Gastroenterology. 2003 Jun;124(7):1950-7.
17	Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
18	In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. Pharm Res. 2005 Apr;22(4):512-7.
19	Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs. Cancer Lett. 2005 Dec 8;230(1):72-80.
20	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
21	Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
22	Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter. Mol Pharmacol. 2012 Mar;81(3):319-27.
23	Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
24	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
25	Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro. Int J Pharm. 2015 Nov 10;495(1):588-598.
26	Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
27	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
28	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
29	Differential recognition of ACE inhibitors in Xenopus laevis oocytes expressing rat PEPT1 and PEPT2. Pharm Res. 2000 May;17(5):526-32.
30	Role of insulin on jejunal PepT1 expression and function regulation in diabetic male and female rats. Can J Physiol Pharmacol. 2010 Jul;88(7):753-9.
31	The apical uptake transporter of levofloxacin is distinct from the peptide transporter in human intestinal epithelial Caco-2 cells. Drug Metab Pharmacokinet. 2008;23(5):373-8.
32	Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon carcinoma cell line Caco-2. Biochim Biophys Acta. 2014 Jun;1840(6):1747-54.
33	Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2. Pharm Res. 2003 Sep;20(9):1389-93.
34	Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G851-6.
35	Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
36	Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
37	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
38	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
39	Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine. J Pharmacol Exp Ther. 2010 Jan;332(1):220-8.
40	Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutr. 2005 Jun;135(6):1491-5.
41	Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 984).
42	Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41.
43	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
44	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
45	Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011;77(2):327-31.
46	Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands. Endocrinology. 2010;151(9):4515-26.
47	DNA methylation alterations in response to pesticide exposure in vitro. Environ Mol Mutagen. 2012;53(7):542-9.
48	Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr Dis Treat. 2010 Jun 24;6:317-27.
49	Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9.
50	Inhibitory effect of zinc on the absorption of JBP485 via the gastrointestinal oligopeptide transporter (PEPT1) in rats. Drug Metab Pharmacokinet. 2011;26(5):494-502.
51	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
52	Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.
53	Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.

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