General Information of Drug Transporter (DT)
DT ID	DTD0526 Transporter Info
Gene Name	SCN1A
Transporter Name	Voltage-gated sodium channel alpha Nav1.1
Gene ID	6323
UniProt ID	P35498
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6J8E_A		Identity	86.203%
Performance	Minimized Score	-2972.573 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	-1.32 ±0.17
	Residues in Favored Region	1919	Ramachandran favored	95.62%
	Number of Outliers	19	Ramachandran outliers	0.95%
Local Quality
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	QMEANBrane Score		0.72
AlphaFold Protein Structure Database	P35498 Click to jump to the details page
SWISS-MODEL Database	P35498 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
7DTD	EM	3.3 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	2052		Mutation	No
References
1	Comparative structural analysis of human Na(v)1.1 and Na(v)1.5 reveals mutational hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021;118(11).

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