Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0440 Transporter Info | |||||
| Gene Name | SLC6A1 | |||||
| Transporter Name | Sodium- and chloride-dependent GABA transporter 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 4XPT_A | Identity | 45.996% | |||
| Performance | Minimized Score | -1424.064 kcal/mol | ||||
| Ramachandra Favored | Medium |
|||||
| QMEANBrane Quality | High |
|||||
| Ramachandran Plot |
|
|||||
| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -1.19 ±0.32 | |||||
| Residues in Favored Region | 519 | Ramachandran favored | 97.56% | |||
| Number of Outliers | 4 | Ramachandran outliers | 0.75% | |||
| Local Quality |
|
|||||
| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.83 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 7SK2 | EM | 3.82 Å | Spodoptera frugiperda | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 578 | Mutation | No | |||
| 7Y7V | EM | 2.2 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 632 | Mutation | No | |||
| 7Y7W | EM | 2.4 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 632 | Mutation | No | |||
| 7Y7Y | EM | 2.4 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 632 | Mutation | No | |||
| 7Y7Z | EM | 3.2 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 632 | Mutation | No | |||
| References | ||||||
| 1 | Structural basis of GABA reuptake inhibition. Nature. 2022;606(7915):820-826. | |||||
| 2 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat Struct Mol Biol. 2023;30(7):1012-1022. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.