General Information of Drug Transporter (DT)
DT ID	DTD0130 Transporter Info
Gene Name	SLC1A2
Transporter Name	Excitatory amino acid transporter 2
Gene ID	6506
UniProt ID	P43004
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	5LLU_A		Identity	59.959%
Performance	Minimized Score	-1271.034 kcal/mol
	Ramachandra Favored	Excellent
	QMEANBrane Quality	High
Ramachandran Plot
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	Ramz Z Score	-1.46 ±0.34
	Residues in Favored Region	469	Ramachandran favored	98.32%
	Number of Outliers	0	Ramachandran outliers	0.00%
Local Quality
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	QMEANBrane Score		0.8
AlphaFold Protein Structure Database	P43004 Click to jump to the details page
SWISS-MODEL Database	P43004 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
7VR7	EM	3.49 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	581		Mutation	No
7VR8	EM	3.58 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	581		Mutation	No
7XR4	EM	3.4 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	574		Mutation	No
7XR6	EM	3.4 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	574		Mutation	No
References
1	Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2. Nat Commun. 2022;13(1):4714.
2	Structural basis of ligand binding modes of human EAAT2. Nat Commun. 2022;13(1):3329.

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