General Information of Drug Transporter (DT)
DT ID	DTD0129 Transporter Info
Gene Name	SLC1A1
Transporter Name	Excitatory amino acid transporter 3
Gene ID	6505
UniProt ID	P43005
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Loop building
Template PDB	6S3Q_A		Identity	98.763%
Performance	Minimized Score	-1266.824 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	High
Ramachandran Plot
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	Ramz Z Score	-1.35 ±0.35
	Residues in Favored Region	450	Ramachandran favored	96.77%
	Number of Outliers	4	Ramachandran outliers	0.86%
Local Quality
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	QMEANBrane Score		0.82
AlphaFold Protein Structure Database	P43005 Click to jump to the details page
SWISS-MODEL Database	P43005 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
6S3Q	EM	3.34 Å	Spodoptera frugiperda	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B/C
Sequence Length	1-480		Mutation	Yes
6X2L	EM	2.85 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	526		Mutation	No
6X2Z	EM	3.03 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A
Sequence Length	526		Mutation	No
6X3E	EM	3.42 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	526		Mutation	No
6X3F	EM	3.03 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	526		Mutation	No
7NSG	EM	3.34 Å	Spodoptera frugiperda	Click to Show/Hide the Details
Structure
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Corresponding chain	A/B/C
Sequence Length	487		Mutation	No
8CTC	EM	2.8 Å	Homo sapiens	Click to Show/Hide the Details	[3]
Structure
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Corresponding chain	A/B/C
Sequence Length	526		Mutation	No
8CTD	EM	3.42 Å	Homo sapiens	Click to Show/Hide the Details	[3]
Structure
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Corresponding chain	A
Sequence Length	526		Mutation	No
References
1	RCSB PDB: Structure of human excitatory amino acid transporter 3 (EAAT3)
2	Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport. Sci Adv. 2021;7(10).
3	Symport and antiport mechanisms of human glutamate transporters. Nat Commun. 2023;14(1):2579.

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