Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0099 Transporter Info | |||||
| Gene Name | SLC15A4 | |||||
| Transporter Name | Peptide transporter 4 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 3F1R_A; 3WIQ_A; 6EI3_A | Identity | 63.636; 21.818; 23.952% | |||
| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -2.31 ±0.35 | |||||
| Residues in Favored Region | 454 | Ramachandran favored | 92.46% | |||
| Number of Outliers | 5 | Ramachandran outliers | 1.02% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.74 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8JZR | EM | 3.25 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | B | |||||
| Sequence Length | 581 | Mutation | No | |||
| 8JZS | EM | 2.95 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 619 | Mutation | No | |||
| 8JZU | EM | 3.05 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 619 | Mutation | No | |||
| 8JZX | EM | 2.5 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/B | |||||
| Sequence Length | 581 | Mutation | No | |||
| 8P6A | EM | 3.63 Å | Homo sapiens | |||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 587 | Mutation | No | |||
| 8QSK | EM | 3.3 Å | Spodoptera frugiperda | |||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/C | |||||
| Sequence Length | 577 | Mutation | No | |||
| 8QSL | EM | 2.81 Å | Spodoptera frugiperda | |||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A/C | |||||
| Sequence Length | 577 | Mutation | No | |||
| 8QSM | EM | 3.69 Å | Spodoptera frugiperda | |||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 577 | Mutation | No | |||
| References | ||||||
| 1 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun. 2023;14(1):6627. | |||||
| 2 | A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun. 2023;14(1):6626. | |||||
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