General Information of Drug Transporter (DT)
DT ID	DTD0084 Transporter Info
Gene Name	SLC12A3
Transporter Name	Thiazide-sensitive sodium-chloride cotransporter
Gene ID	6559
UniProt ID	P55017
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6NPL_A		Identity	52.231%
Performance	Minimized Score	-97.798 kcal/mol
	Ramachandra Favored	Poor
	QMEANBrane Quality	Poor
Ramachandran Plot
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	Ramz Z Score	-3.2 ±0.26
	Residues in Favored Region	759	Ramachandran favored	85.96%
	Number of Outliers	41	Ramachandran outliers	4.64%
Local Quality
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	QMEANBrane Score		0.54
AlphaFold Protein Structure Database	P55017 Click to jump to the details page
SWISS-MODEL Database	P55017 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
7Y6I	EM	2.85 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B
Sequence Length	1053		Mutation	No
7YG0	EM	3.75 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B
Sequence Length	1053		Mutation	No
7YG1	EM	3.77 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A/B
Sequence Length	1053		Mutation	No
8FHN	EM	3 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	1092		Mutation	No
8FHO	EM	2.95 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	A/B/C
Sequence Length	1092		Mutation	No
8FHP	EM	3.04 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	N.A.
Sequence Length	N.A.		Mutation	No
8FHQ	EM	2.81 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	N.A.
Sequence Length	N.A.		Mutation	No
8FHR	EM	2.9 Å	Homo sapiens	Click to Show/Hide the Details	[2]
Structure
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Corresponding chain	N.A.
Sequence Length	N.A.		Mutation	No
References
1	Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv. 2022;8(45):eadd7176.
2	Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature. 2023;614(7949):788-793.

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