Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0042 Transporter Info | |||||
| Gene Name | ABCA4 | |||||
| Transporter Name | ATP-binding cassette sub-family A member 4 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Detail Information of Structural Model | ||||||
| Method | Homology modeling | |||||
| Template PDB | 5XJY_A | Identity | 50.35% | |||
| Performance | Minimized Score | -1123.451 kcal/mol | ||||
| Ramachandra Favored | Poor |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
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| Click to Save Ramachandran Plot in PNG Format | ||||||
| Ramz Z Score | -2.33 ±0.16 | |||||
| Residues in Favored Region | 2033 | Ramachandran favored | 90.20% | |||
| Number of Outliers | 62 | Ramachandran outliers | 2.75% | |||
| Local Quality |
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| Click to Save Local Quality Plot in PNG Format | ||||||
| QMEANBrane Score | 0.67 | |||||
| AlphaFold Protein Structure Database | ||||||
| SWISS-MODEL Database | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 7E7I | EM | 3.3 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2317 | Mutation | No | |||
| 7E7O | EM | 3.4 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2317 | Mutation | No | |||
| 7E7Q | EM | 3.3 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2317 | Mutation | No | |||
| 7LKP | EM | 3.27 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2273 | Mutation | No | |||
| 7LKZ | EM | 3.27 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2273 | Mutation | No | |||
| 7M1P | EM | 3.6 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2273 | Mutation | No | |||
| 7M1Q | EM | 2.92 Å | Homo sapiens | [3] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2273 | Mutation | No | |||
| 8F5B | EM | 3.95 Å | Homo sapiens | [4] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 2273 | Mutation | No | |||
| References | ||||||
| 1 | Structural basis of substrate recognition and translocation by human ABCA4. Nat Commun. 2021;12(1):3853. | |||||
| 2 | Molecular structures of the eukaryotic retinal importer ABCA4. Elife. 2021;10. | |||||
| 3 | Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nat Commun. 2021;12(1):5902. | |||||
| 4 | Structural and functional characterization of the nucleotide-binding domains of ABCA4 and their role in Stargardt disease. J Biol Chem. 2024;300(9):107666. | |||||
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