Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0027 Transporter Info | |||||
| Gene Name | SLC22A12 | |||||
| Transporter Name | Urate anion exchanger 1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8WJG | EM | 3 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 538 | Mutation | No | |||
| 8WJQ | EM | 3.8 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 538 | Mutation | No | |||
| 9B1F | EM | 2.9 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 547 | Mutation | No | |||
| 9B1G | EM | 2.7 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 547 | Mutation | No | |||
| 9B1H | EM | 2.9 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 547 | Mutation | No | |||
| 9B1I | EM | 3.7 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 547 | Mutation | No | |||
| 9B1J | EM | 3 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 547 | Mutation | No | |||
| 9B1K | EM | 3.3 Å | Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 547 | Mutation | No | |||
| Modelled Structures of This DT | ||||||
| Click to Save PDB File in PDB Format | ||||||
| Detail Information of Modelled Structures | ||||||
| Method | multi-sequence alignment based machine learning | |||||
| AlphaFold Protein Structure Database | ||||||
| References | ||||||
| 1 | Structural basis for the transport and substrate selection of human urate transporter 1. Cell Rep. 2024;43(8):114628. | |||||
| 2 | Transport mechanism and structural pharmacology of human urate transporter URAT1. Cell Res. 2024;34(11):776-787. | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.