General Information of Drug Transporter (DT)
DT ID	DTD0016 Transporter Info
Gene Name	ABCC5
Transporter Name	Multidrug resistance-associated protein 5
Gene ID	10057
UniProt ID	O15440
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	5UJ9_A		Identity	38.53%
Performance	Minimized Score	-2759.769 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	-1.16 ±0.21
	Residues in Favored Region	1275	Ramachandran favored	96.30%
	Number of Outliers	10	Ramachandran outliers	0.76%
Local Quality
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	QMEANBrane Score		0.77
AlphaFold Protein Structure Database	O15440 Click to jump to the details page
SWISS-MODEL Database	O15440 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8KCI	EM	3.94 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1437		Mutation	No
8WI2	EM	4.06 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	B
Sequence Length	19		Mutation	No
8WI3	EM	3.38 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1473		Mutation	No
8WI4	EM	3.2 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1437		Mutation	No
8WI5	EM	3.46 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	B
Sequence Length	24		Mutation	No
References
1	Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun. 2024;15(1):4811.

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