General Information of Drug Transporter (DT)
DT ID	DTD0012 Transporter Info
Gene Name	ABCC3
Transporter Name	Multidrug resistance-associated protein 3
Gene ID	8714
UniProt ID	O15438
Modelled Structures of This DT
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Detail Information of Structural Model
Method	Homology modeling
Template PDB	6UY0_A		Identity	57.19%
Performance	Minimized Score	-3311.772 kcal/mol
	Ramachandra Favored	Medium
	QMEANBrane Quality	Medium
Ramachandran Plot
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	Ramz Z Score	-1.12 ±0.19
	Residues in Favored Region	1474	Ramachandran favored	97.55%
	Number of Outliers	6	Ramachandran outliers	0.40%
Local Quality
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	QMEANBrane Score		0.77
AlphaFold Protein Structure Database	O15438 Click to jump to the details page
SWISS-MODEL Database	O15438 Click to jump to the details page
Experimental Structures of This DT
PDB ID	Scanning Method	Resolution	Expression System	Details	Ref
8HVH	EM	3.07 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1527		Mutation	No
8HW2	EM	3.65 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1527		Mutation	No
8HW4	EM	3.52 Å	Homo sapiens	Click to Show/Hide the Details	[1]
Structure
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Corresponding chain	A
Sequence Length	1527		Mutation	No
8IZP	EM	3.31 Å	Homo sapiens	Click to Show/Hide the Details
Structure
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Corresponding chain	A
Sequence Length	1571		Mutation	No
References
1	Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket. EMBO J. 2023;42(17):e113415.

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