Detail Information of DT Wildtype Structure
| General Information of Drug Transporter (DT) | ||||||
|---|---|---|---|---|---|---|
| DT ID | DTD0008 Transporter Info | |||||
| Gene Name | SLCO1B1 | |||||
| Transporter Name | Organic anion transporting polypeptide 1B1 | |||||
| Gene ID | ||||||
| UniProt ID | ||||||
| Experimental Structures of This DT | ||||||
| PDB ID | Scanning Method | Resolution | Expression System | Details | Ref | |
| 8HNB | EM | 3.53 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 712 | Mutation | No | |||
| 8HNC | EM | 3.73 Å | Homo sapiens | [1] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 712 | Mutation | No | |||
| 8HND | EM | 3.19 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 724 | Mutation | No | |||
| 8HNH | EM | 3.73 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 724 | Mutation | No | |||
| 8K6L | EM | 2.92 Å | Homo sapiens | [1] | ||
| Structure | ||||||
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| Corresponding chain | A | |||||
| Sequence Length | 724 | Mutation | No | |||
| 8PHW | EM | 3.6 Å | Escherichia coli,Homo sapiens | [2] | ||
| Structure | ||||||
| Click to Save PDB File in TXT Format | ||||||
| Corresponding chain | A | |||||
| Sequence Length | 691 | Mutation | No | |||
| Modelled Structures of This DT | ||||||
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| Detail Information of Modelled Structures | ||||||
| Method | multi-sequence alignment based machine learning | |||||
| AlphaFold Protein Structure Database | ||||||
| References | ||||||
| 1 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res. 2023;33(12):940-951. | |||||
| 2 | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun. 2023;14(1):5774. | |||||
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