Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0521 | ||||
| Gene Name | CACNA2D3 | ||||
| Protein Name | Voltage-dependent calcium channel alpha-2/delta-3 | ||||
| Gene ID | |||||
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| 3D Structure |
Modelled DT Structure Method: multi-sequence alignment based machine learning Detail: Structure Info |
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| Synonyms | CACNA2D3; HSA272268; Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3; Voltage-gated calcium channel subunit alpha-2/delta-3; Voltage-dependent calcium channel subunit alpha-2/delta-3 | ||||
| DT Family | Ca(2+) Channel Auxiliary Subunit Alpha2Delta Types 1-4 (CCA-Alpha2Delta) Family ; | ||||
| Tissue Specificity | Only detected in brain. Not present in lung,testis, aorta, spleen, jejunum, ventricular muscle and kidney (atprotein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widelyexpressed. | ||||
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. | ||||
| Endogenous Substrate(s) | Ca2+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Voltage-dependent calcium channel alpha-2/delta-3 |
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(β) Cell Distribution Level of Voltage-dependent calcium channel alpha-2/delta-3 |
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(γ) Organelle Distribution Level of Voltage-dependent calcium channel alpha-2/delta-3 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Voltage-dependent calcium channel alpha-2/delta-3 |
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(γ) Transcriptional Regulation of Voltage-dependent calcium channel alpha-2/delta-3 |
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(δ) Epigenetic Regulation of Voltage-dependent calcium channel alpha-2/delta-3 |
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(ε) Exogenous Modulation of Voltage-dependent calcium channel alpha-2/delta-3 |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Voltage-dependent calcium channel alpha-2/delta-3 |
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(β) Disease-specific Protein Abundances of Voltage-dependent calcium channel alpha-2/delta-3 |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.