Modelled DT Structure
Method:homology modeling
Template PDB:6M17_A
Identity:53.704%
Minimized Score:-1493.93 kcal/mol
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0450 | ||||
| Gene Name | SLC6A18 | ||||
| Protein Name | Sodium-dependent neutral amino acid transporter B(0)AT3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | SLC6A18; Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; Inactive sodium-dependent neutral amino acid transporter B(0)AT3; XTRP2; B(0)AT3; System B(0) neutral amino acid transporter AT3 | ||||
| DT Family | Neurotransmitter:Sodium Symporter (NSS) Family ; | ||||
| Tissue Specificity | Abundantly expressed in kidney, but not inintestine. | ||||
| Function | This transporter does not show neutral amino acid transporter activity. | ||||
| Endogenous Substrate(s) | Neutral amino acids | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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(β) Cell Distribution Level of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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(γ) Organelle Distribution Level of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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(δ) Epigenetic Regulation of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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(ε) Exogenous Modulation of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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(γ) Outward/inward-facing Conformation |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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(β) Disease-specific Protein Abundances of Sodium-dependent neutral amino acid transporter B(0)AT3 |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Approved Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Amino acids
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Approved | Drug Info | Nutritional deficiency | 5B7Z | [1] |
| References | |||||
| 1 | Spatial mRNA Expression and Response to Fasting and Refeeding of Neutral Amino Acid Transporters slc6a18 and slc6a19a in the Intestinal Epithelium of Mozambique tilapia. Front Physiol. 2018 Mar 13;9:212. | ||||
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