Drug Transporter (DT) Information

General Information of DT
DT ID DTD0445
Gene Name SLC6A13
Protein Name Sodium- and chloride-dependent GABA transporter 2
Gene ID
6540
UniProt ID
Q9NSD5
TCDB ID
2.A.22.3.10
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4XPH_A

Identity:46.972%

Minimized Score:-1472.193 kcal/mol

Detail: Structure Info

Synonyms GAT-2; GAT2; SLC6A13; Solute carrier family 6 member 13
DT Family Neurotransmitter:Sodium Symporter (NSS) Family ;
Tissue Specificity Expressed in brain, kidney, lung, liver andtestis.
Function This sodium-dependent transporter is for GABA and taurine and may also be involved in beta-alanine transport. In presynaptic terminals, regulates GABA signaling termination through GABA uptake.
Endogenous Substrate(s) Cl-; Gamma-aminobutyric acid; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium- and chloride-dependent GABA transporter 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium- and chloride-dependent GABA transporter 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium- and chloride-dependent GABA transporter 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium- and chloride-dependent GABA transporter 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium- and chloride-dependent GABA transporter 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium- and chloride-dependent GABA transporter 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium- and chloride-dependent GABA transporter 2
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

(γ) Outward/inward-facing Conformation
Outward/inward-facing Conformation (OIC)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium- and chloride-dependent GABA transporter 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium- and chloride-dependent GABA transporter 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Clinical Trial Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Beta-alanine
 Phase 4 Drug Info Muscle function VC01 [1]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Gamma-aminobutyric acid
119
EM Info Identified using SLC6A6 knockout DLD-1 and HeLa cells [2]
References
1 Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7.
2 Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells. Photochem Photobiol. 2014 Sep-Oct;90(5):1136-43.

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