Drug Transporter (DT) Information

General Information of DT
DT ID DTD0415
Gene Name SLC58A2
Protein Name Tumor suppressor candidate 3
Gene ID
7991
UniProt ID
Q13454
TCDB ID
1.A.76.1.2
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:4M91_A_A

Identity:98.675%

Minimized Score:-469.597 kcal/mol

Detail: Structure Info

Synonyms D8S1992; M33; MRT22; MRT7; MagT2; N33; OST3A; SLC58A2; TUSC3
DT Family Magnesium Transporter1 (MAGT1) Family ;
Function This transporter acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates.
Endogenous Substrate(s) Mg2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Tumor suppressor candidate 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Tumor suppressor candidate 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Tumor suppressor candidate 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Tumor suppressor candidate 3
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Tumor suppressor candidate 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Tumor suppressor candidate 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(α) Mutation-induced Structural Variation
Mutation-induced Structural Variation (MSV)

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Tumor suppressor candidate 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Tumor suppressor candidate 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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