Drug Transporter (DT) Information

General Information of DT
DT ID DTD0414
Gene Name SLC58A1
Protein Name Magnesium transporter protein 1
Gene ID
84061
UniProt ID
Q9H0U3
TCDB ID
1.A.76.1.1
3D Structure

Crystal Structure

Crystallisation Method:EM

PDB ID:6S7T

Corresponding Chain:H

Sequence Length:1-335

Detail: Struture Info

Synonyms Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; IAG2; IAP; Implantation-associated protein; MRX95; MagT1; OST3B; Oligosaccharyl transferase subunit MAGT1; PRO0756; PSEC0084; SLC58A1; UNQ628/PRO1244; XMEN; bA217H1.1
DT Family Magnesium Transporter1 (MAGT1) Family ;
Function This transporter acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates.
Endogenous Substrate(s) Mg2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Magnesium transporter protein 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Magnesium transporter protein 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Magnesium transporter protein 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Magnesium transporter protein 1
Microbiota Influence (MBI)

(β) Post-translational Modification of Magnesium transporter protein 1
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Magnesium transporter protein 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Magnesium transporter protein 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Magnesium transporter protein 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Magnesium transporter protein 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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