Drug Transporter (DT) Information

General Information of DT
DT ID DTD0408
Gene Name SLC57A1
Protein Name Magnesium transporter NIPA1
Gene ID
123606
UniProt ID
Q7RTP0
TCDB ID
2.A.7.25.1
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms FSP3; NIPA1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 1; SLC57A1; SPG6; Spastic paraplegia 6 protein
DT Family Drug/Metabolite Transporter (DMT) Superfamily
NIPA Mg2+ Uptake Permease (NIPA) Family
Function This tranaporter mediates the transport of divalent cations such as Mg(2+), Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+).
Endogenous Substrate(s) Mg2+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Magnesium transporter NIPA1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Magnesium transporter NIPA1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Magnesium transporter NIPA1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Magnesium transporter NIPA1
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Magnesium transporter NIPA1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Magnesium transporter NIPA1
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Magnesium transporter NIPA1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Magnesium transporter NIPA1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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