Drug Transporter (DT) Information

General Information of DT
DT ID DTD0392
Gene Name SLC51B
Protein Name Organic solute transporter subunit beta
Gene ID
123264
UniProt ID
Q86UW2
TCDB ID
2.A.82.1.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms OST-beta; OSTB; OSTBETA; SLC51B; Solute carrier family 51 subunit beta
DT Family Organic Solute Transporter (OST) Family ;
Tissue Specificity Widely expressed with a high expression inileum. Expressed in testis, colon, liver, small intestine, kidney,ovary and adrenal gland; and at low levels in heart, lung, brain,pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
Function This transporter is essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
Endogenous Substrate(s) Dehydroepiandrosterone sulfate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Organic solute transporter subunit beta
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Organic solute transporter subunit beta
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Organic solute transporter subunit beta
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Organic solute transporter subunit beta
Microbiota Influence (MBI)

(β) Post-translational Modification of Organic solute transporter subunit beta
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Organic solute transporter subunit beta
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Organic solute transporter subunit beta
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Organic solute transporter subunit beta
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Organic solute transporter subunit beta
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Organic solute transporter subunit beta
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           6 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Digoxin
 Approved Drug Info Arrhythmias BC60-BC9Z [1]
Digoxin
 Approved Drug Info Arrhythmias BC60-BC9Z [1]
Dinoprostone
 Approved Drug Info Medical abortion JA00.1 [1]
Dinoprostone
 Approved Drug Info Medical abortion JA00.1 [1]
Estrone sulfate
 Approved Drug Info Menopausal symptoms MF32 [1]
Estrone sulfate
 Approved Drug Info Menopausal symptoms MF32 [1]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Sodium taurocholate
 Preclinical Drug Info Type 2 diabetes 5A11 [2]
Taurocholic acid
 Terminated Drug Info Type 2 diabetes 5A11 [1]

Drug-DT Affinity Assessed by Cell Line

 Approved Drug

 Click to Show/Hide the Full List of Drug:         22 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
Estrone sulfate Approved Drug Info Oocytes-OSTalpha-OSTbeta Km =320 microM []
References
1 Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82.
2 OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9.

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