Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
| General Information of DT | |||||
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| DT ID | DTD0284 | ||||
| Gene Name | SLC34A1 | ||||
| Protein Name | Sodium-dependent phosphate transport protein 2A | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
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| Synonyms | FRTS2; HCINF2; NPHLOP1; NPT2; NPTIIa; Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; NaPi-2a; NaPi-3; SLC11; SLC34A1; Sodium-phosphate transport protein 2A; Sodium/phosphate cotransporter 2A; Solute carrier family 34 member 1 | ||||
| DT Family | Phosphate:Na(+) Symporter (PNAS) Family ; | ||||
| Tissue Specificity | Kidney and lung. | ||||
| Function | This transporter involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Mediates 70-80% of the apical influx. | ||||
| Endogenous Substrate(s) | Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent phosphate transport protein 2A |
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(β) Cell Distribution Level of Sodium-dependent phosphate transport protein 2A |
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(γ) Organelle Distribution Level of Sodium-dependent phosphate transport protein 2A |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-dependent phosphate transport protein 2A |
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(γ) Transcriptional Regulation of Sodium-dependent phosphate transport protein 2A |
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(δ) Epigenetic Regulation of Sodium-dependent phosphate transport protein 2A |
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(ε) Exogenous Modulation of Sodium-dependent phosphate transport protein 2A |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent phosphate transport protein 2A |
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(β) Disease-specific Protein Abundances of Sodium-dependent phosphate transport protein 2A |
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(γ) Species- and Tissue-specific DT Abundances |
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| Molecular Transporting Profile of This DT | |||||
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Full List of Drug(s) Transported by This DT |
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Clinical Trial Drug |
Click to Show/Hide the Full List of Drug: 1 Drugs in Total | ||||
| Drug Name | Highest Status | Detail | Indication | ICD 11 | Ref |
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Calcium phosphate
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Phase 2 | Drug Info | Osteoporosis | FB83.1 | [1] |
| References | |||||
| 1 | Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. | ||||
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