Drug Transporter (DT) Information

General Information of DT
DT ID DTD0278
Gene Name SLC31A1
Protein Name High affinity copper uptake protein 1
Gene ID
1317
UniProt ID
O15431
TCDB ID
1.A.56.1.2
3D Structure

Crystal Structure

Crystallisation Method:NMR

PDB ID:2LS2

Corresponding Chain:A

Sequence Length:64-87

Detail: Struture Info

Synonyms COPT1; CTR1; Copper transporter 1; SLC31A1; Solute carrier family 31 member 1; hCTR1
DT Family Copper Transporter (CTR) Family ;
Function This high-affinity transporter involved in dietary copper uptake.
Disease(s) Emesis [ICD-11:MD90]
Ovarian cancer [ICD-11:2C73]
Endogenous Substrate(s) Ag+; Cu+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of High affinity copper uptake protein 1
Tissue Distribution Level (TD)

(β) Cell Distribution Level of High affinity copper uptake protein 1
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of High affinity copper uptake protein 1
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of High affinity copper uptake protein 1
Microbiota Influence (MBI)

(β) Post-translational Modification of High affinity copper uptake protein 1
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of High affinity copper uptake protein 1
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of High affinity copper uptake protein 1
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of High affinity copper uptake protein 1
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of High affinity copper uptake protein 1
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of High affinity copper uptake protein 1
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           3 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Carboplatin
 Approved Drug Info Ovarian cancer 2C73 [1]
Cisplatin
 Approved Drug Info Testicular cancer 2C80 [1]
Oxaliplatin
 Approved Drug Info Colorectal cancer 2B91 [2]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cupric sulfate
 Preclinical Drug Info Diabetes 5A10-5A14 [3]
References
1 Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61.
2 Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs. Crit Rev Oncol Hematol. 2005 Jan;53(1):13-23.
3 Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci. 2010 Jul 14;30(28):9500-9.

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