| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0226 | ||||
| Gene Name | SLC25A9 | ||||
| Protein Name | Mitochondrial uncoupling protein 3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:2LCK_A Identity:73.09% Minimized Score:-467.227 kcal/mol Detail: Structure Info |
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| Synonyms | SLC25A9; Solute carrier family 25 member 9; UCP 3; UCP3 | ||||
| DT Family | Mitochondrial Carrier (MC) Family ; | ||||
| Tissue Specificity | Only in skeletal muscle and heart. Is moreexpressed in glycolytic than in oxidative skeletal muscles. | ||||
| Function | This transporter is mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. It may play a role in the modulation of tissue respiratory control. It participates in thermogenesis and energy balance. | ||||
| Endogenous Substrate(s) | H+; Cl- | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Mitochondrial uncoupling protein 3 |
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(β) Cell Distribution Level of Mitochondrial uncoupling protein 3 |
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(γ) Organelle Distribution Level of Mitochondrial uncoupling protein 3 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Mitochondrial uncoupling protein 3 |
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(γ) Transcriptional Regulation of Mitochondrial uncoupling protein 3 |
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(δ) Epigenetic Regulation of Mitochondrial uncoupling protein 3 |
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(ε) Exogenous Modulation of Mitochondrial uncoupling protein 3 |
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Structural Variability Data of This DT |
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(β) Inter-species Structural Differences |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Mitochondrial uncoupling protein 3 |
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(β) Disease-specific Protein Abundances of Mitochondrial uncoupling protein 3 |
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(γ) Species- and Tissue-specific DT Abundances |
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