Drug Transporter (DT) Information

General Information of DT
DT ID DTD0194
Gene Name SLC25A32
Protein Name Mitochondrial folate transporter/carrier
Gene ID
81034
UniProt ID
Q9H2D1
TCDB ID
2.A.29.10.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms MFT; MFTC; RREI; SLC25A32; Solute carrier family 25 member 32
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Ubiquitous.
Function This transporter is for folate across the inner membranes of mitochondria.
Endogenous Substrate(s) Folate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Mitochondrial folate transporter/carrier
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Mitochondrial folate transporter/carrier
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Mitochondrial folate transporter/carrier
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Mitochondrial folate transporter/carrier
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Mitochondrial folate transporter/carrier
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Mitochondrial folate transporter/carrier
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Mitochondrial folate transporter/carrier
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Mitochondrial folate transporter/carrier
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Mitochondrial folate transporter/carrier
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Folic acid
 Approved Drug Info Vitamin deficiency 5B55-5B7Z [1]
References
1 Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women. Geriatr Gerontol Int. 2014 Oct;14(4):942-6.

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