Drug Transporter (DT) Information

General Information of DT
DT ID DTD0167
Gene Name SLC25A1
Protein Name Tricarboxylate transport protein
Gene ID
6576
UniProt ID
P53007
TCDB ID
2.A.29.7.2
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms CMS23; CTP; Citrate transport protein; D2L2AD; SEA; SLC20A3; SLC25A1; Solute carrier family 25 member 1; Tricarboxylate carrier protein
DT Family Mitochondrial Carrier (MC) Family ;
Function This transporter regulates the movement of citrate across the inner membranes of the mitochondria. It also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate.
Endogenous Substrate(s) Citrate; Malate; PEP; H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Tricarboxylate transport protein
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Tricarboxylate transport protein
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Tricarboxylate transport protein
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Tricarboxylate transport protein
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Tricarboxylate transport protein
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Tricarboxylate transport protein
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Tricarboxylate transport protein
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Tricarboxylate transport protein
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Tricarboxylate transport protein
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Citrate
311
EM Info Identified using peripheral blood monocytic cells [1]
References
1 Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome. J Biol Chem. 2015 Sep 18;290(38):23240-53.

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