Drug Transporter (DT) Information

General Information of DT
DT ID DTD0076
Gene Name SLC10A4
Protein Name Sodium/bile acid cotransporter 4
Gene ID
201780
UniProt ID
Q96EP9
TCDB ID
2.A.28.1.7
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Na(+)/bile acid cotransporter 4; SLC10A4; Solute carrier family 10 member 4
DT Family Bile Acid:Na(+) Symporter (BASS) Family ;
Tissue Specificity Highly expressed in brain and small intestine,and moderately expressed in colon, heart, prostate, and testis.Very low levels were detected in kidney, liver, ovary, placenta,spleen, and thymus.
Function This transporter use for transporting bile acids.
Endogenous Substrate(s) Bile acids; Na+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/bile acid cotransporter 4
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/bile acid cotransporter 4
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/bile acid cotransporter 4
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Sodium/bile acid cotransporter 4
Post-translational Modification (PTM)

(δ) Epigenetic Regulation of Sodium/bile acid cotransporter 4
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/bile acid cotransporter 4
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/bile acid cotransporter 4
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/bile acid cotransporter 4
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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